Multi-modal approach using Raman spectroscopy and optical coherence tomography for the discrimination of colonic adenocarcinoma from normal colon
Multi-modal approach using Raman spectroscopy and optical coherence tomography for the discrimination of colonic adenocarcinoma from normal colon
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DOI：
10.1364/boe.4.002179
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发表时间：
2013-10-01
影响因子：
3.4
通讯作者：
Herrington, C. Simon
中科院分区：
文献类型：
--
作者：
Ashok, Praveen C.;Praveen, Bavishna B.;Herrington, C. Simon
我们报告了一种多模态光学方法，同时使用拉曼光谱和光学相干断层扫描（OCT）串联，以区分结肠腺癌和正常结肠。虽然这两种非侵入性技术都能够区分正常组织和肿瘤组织，但它们不能单独提供疾病诊断所需的高特异性和高灵敏度。我们将联合收割机从拉曼光谱中得到的化学信息与从OCT图像中提取的纹理参数相结合。拉曼光谱法和OCT法的敏感性分别为89%和78%，特异性分别为77%和74%。结合使用这两种技术获得的信息将灵敏度和特异性提高到94%，表明结合互补的光学信息提高了诊断准确性。这些数据表明，多模态光学分析有可能实现准确的非侵入性癌症诊断。(C)2013年美国光学学会
We report a multimodal optical approach using both Raman spectroscopy and optical coherence tomography (OCT) in tandem to discriminate between colonic adenocarcinoma and normal colon. Although both of these non-invasive techniques are capable of discriminating between normal and tumour tissues, they are unable individually to provide both the high specificity and high sensitivity required for disease diagnosis. We combine the chemical information derived from Raman spectroscopy with the texture parameters extracted from OCT images. The sensitivity obtained using Raman spectroscopy and OCT individually was 89% and 78% respectively and the specificity was 77% and 74% respectively. Combining the information derived using the two techniques increased both sensitivity and specificity to 94% demonstrating that combining complementary optical information enhances diagnostic accuracy. These data demonstrate that multimodal optical analysis has the potential to achieve accurate non-invasive cancer diagnosis. (C) 2013 Optical Society of America