Palladium-catalyzed intramolecular asymmetric hydroamination of alkynes
Palladium-catalyzed intramolecular asymmetric hydroamination of alkynes
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DOI：
10.1021/ja039774g
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发表时间：
2004-02-18
影响因子：
15
通讯作者：
Yamamoto, Y
中科院分区：
文献类型：
--
作者：
Lutete, LM;Kadota, I;Yamamoto, Y
本文报道了在PhCO_2H和RENORPHOS手性膦配体存在下，Pd催化的内炔与束缚氨基的反应。以良好到高的产率获得了各种五元和六元含氮杂环，具有中等到高的ee。
The Pd-catalyzed reaction of internal alkynes with tethered amino groups in the presence of PhCO2H and RENORPHOS as chiral phosphine ligand is reported. Various five- and six-membered nitrogen-containing heterocycles were obtained in good to high yield with moderate to high ee.