Pamidronate attenuates muscle loss after pediatric burn injury.
Pamidronate attenuates muscle loss after pediatric burn injury.
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DOI：
10.1002/jbmr.2162
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发表时间：
2014-06
影响因子：
6.2
通讯作者：
Klein, Gordon L.
中科院分区：
文献类型：
--
作者：
Borsheim, Elisabet;Herndon, David N.;Hawkins, Hal K.;Suman, Oscar E.;Cotter, Matthew;Klein, Gordon L.
烧伤面积超过全身表面积40%的儿童由于急性骨吸收、炎症和内源性糖皮质激素的产生而失去大量的骨和肌肉质量，这导致负氮平衡。由于在烧伤后10天内给予双膦酸帕米膦酸盐完全防止了骨丢失，我们询问是否通过保留骨改变了肌肉蛋白平衡。我们回顾了17名烧伤儿童受试者的结果，这些受试者先前参加了一项帕米膦酸盐预防烧伤后骨丢失的双盲随机对照研究，并在急性住院期间通过稳定同位素输注研究同时评估了肌肉蛋白合成和分解。我们发现，帕米膦酸组的蛋白质合成率（FSR）明显较低，静脉血中氨基酸示踪剂的出现率相应较低，表明肌肉蛋白质周转率较低。此外，净蛋白平衡（合成减去分解）在接受帕米膦酸盐的受试者中为阳性，而在接受安慰剂的受试者中为阴性。肌肉纤维直径在帕米膦酸盐受试者中显著更大，并且在烧伤后9个月时，接受帕米膦酸盐的受试者与我们实验室研究的正常身体健康年龄匹配的儿童之间的腿部力量没有差异。作为对照的烧伤受试者的腿部力量往往较弱，尽管不是很明显。如果得到更大规模研究的证实，这些结果表明骨骼可能具有保护肌肉的旁分泌机制，这一发现可能对老年人肌肉减少症的治疗有意义。
Children who are burned > 40% total body surface area lose significant quantities of both bone and muscle mass due to acute bone resorption, inflammation and endogenous glucocorticoid production, which result in negative nitrogen balance. Because administration of the bisphosphonate pamidronate within 10d of the burn injury completely prevents the bone loss we asked whether muscle protein balance was altered by the preservation of bone. We reviewed the results from 17 burned pediatric subjects previously enrolled in a double-blind randomized controlled study of pamidronate in the prevention of post-burn bone loss and who were concurrently evaluated for muscle protein synthesis and breakdown by stable isotope infusion studies during the acute hospitalization. We found a significantly lower fractional protein synthesis rate (FSR) in the pamidronate group and a correspondingly lower rate of appearance of the amino acid tracer in venous blood suggesting lower muscle protein turnover. Moreover, net protein balance(synthesis minus breakdown) was positive in the subjects receiving pamidronate and negative in those receiving placebo. Muscle fiber diameter was significantly greater in the pamidronate subjects and leg strength at 9 months post-burn was not different between subjects who received pamidronate and normal physically fit age-matched children studied in our lab. Leg strength in burned subjects who served as controls tended to be weaker, although not quite significantly so. If substantiated by a larger study, these results suggest that bone may have a paracrine mechanism to preserve muscle and this finding may have implications for the treatment of sarcopenia in the elderly.
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影响因子：
3.7
作者：
Jeschke, Marc G.;Williams, Felicia N.;Herndon, David N.
通讯作者：
Herndon, David N.
影响因子：
3.3
作者：
Tang, Kechun;Murano, George;Breen, Ellen C.
通讯作者：
Breen, Ellen C.
影响因子：
3.7
作者：
Sassoli C;Pini A;Chellini F;Mazzanti B;Nistri S;Nosi D;Saccardi R;Quercioli F;Zecchi-Orlandini S;Formigli L
通讯作者：
Formigli L
影响因子：
6.2
作者：
Plotkin, Lilian I.;Lezcano, Virginia;Bellido, Teresita
通讯作者：
Bellido, Teresita
影响因子：
9
作者：
Hart, DW;Wolf, SE;Herndon, DN
通讯作者：
Herndon, DN