Adverse Reactions to Vaccination From Anaphylaxis to Autoimmunity
Adverse Reactions to Vaccination From Anaphylaxis to Autoimmunity
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DOI：
10.1016/j.cvsm.2017.10.005
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发表时间：
2018-03-01
影响因子：
1.9
通讯作者：
Gershwin, Laurel J.
中科院分区：
文献类型：
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作者：
Gershwin, Laurel J.
疫苗对于预防传染病很重要。疫苗接种启动了一个过程，该过程刺激对疫苗中的病原体产生强大且持久的免疫应答。副作用有时与疫苗接种有关。这些变化从对疫苗成分的急性超敏反应发展到令人烦恼但对患者没有显著损害的局部组织反应。这些反应的发病机制和随之而来的临床结果进行了讨论。免疫应答的过度刺激和与自身免疫的潜在关系与遗传易感性有关。
Vaccines are important for providing protection from infectious diseases. Vaccination initiates a process that stimulates development of a robust and long-lived immune response to the disease agents in the vaccine. Side effects are sometimes associated with vaccination. These vary from development of acute hypersensitivity responses to vaccine components to local tissue reactions that are annoying but not significantly detrimental to the patient. The pathogenesis of these responses and the consequent clinical outcomes are discussed. Overstimulation of the immune response and the potential relationship to autoimmunity is evaluated in relation to genetic predisposition.