The Role of Family-Based Designs in Genome-Wide Association Studies
The Role of Family-Based Designs in Genome-Wide Association Studies
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DOI：
10.1214/08-sts280
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发表时间：
2009-11-01
影响因子：
5.7
通讯作者：
Lange, Christoph
中科院分区：
文献类型：
--
作者：
Laird, Nan M.;Lange, Christoph
Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs. Family-based association designs have long been attractive for their robustness properties, but robustness can mean a loss of power. In this paper we discuss some of the special features of family designs and their relevance in the era of GWAS.
