Antioxidant supplementation in pregnant women with low antioxidant status
Antioxidant supplementation in pregnant women with low antioxidant status
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DOI：
10.1111/j.1447-0756.2012.01855.x
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发表时间：
2012-09-01
影响因子：
1.6
通讯作者：
Fitriana, Ika
中科院分区：
文献类型：
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作者：
Wibowo, Noroyono;Purwosunu, Yuditiya;Fitriana, Ika
目的：本研究的目的是研究抗氧化剂补充对低抗氧化状态的女性队列的益处，并确定无细胞mRNA的变化。材料和方法：本研究是一项随机、安慰剂对照试验，812周的孕妇抗氧化剂水平较低，每天服用抗氧化剂或控制饮食，直到产后2周。主要终点是先兆子痫的风险，次要终点是与结果相关的血管生成和抗氧化mRNA标志物的变化（clinicaltrials .gov，编号NCT01232205）。结果：有110名妇女参加了这项研究，随机分配到补充组（n = 52）和对照组（n = 58）。子痫前期总发生率为8.7%（9例）。添加组与对照组子痫前期发生率（分别为2.0%[1例]和14.5%[8例]）、超氧化物歧化酶、血红素加氧酶-1、血管内皮生长因子受体-1、内皮素和胎盘生长因子mRNA水平差异均有统计学意义（P = 0.034）。结论：在妊娠早期向抗氧化能力低的妇女补充含有抗氧化剂的微量营养素可降低先兆子痫的风险。
Aim: The aim of this study was to investigate the benefit of antioxidant supplementation in a cohort of women with low antioxidant status and determine the changes in cell-free mRNA. Material and Methods: This study was a randomized, placebo-controlled trial of 812 weeks' pregnant women who had low antioxidant status treated with either antioxidants or control diets daily until 2 weeks' postpartum. The primary end-point was the risk of pre-eclampsia and the secondary end-point was the changes of angiogenic and anti-oxidant mRNA markers related to the outcome (ClinicalTrial.gov, number NCT01232205). Results: There were 110 women enrolled in the study, randomly assigned to the supplementation (n = 52) and control group (n = 58). The overall rate of pre-eclampsia was 8.7% (nine subjects). There were significant differences (P = 0.034) between the supplementation and control group in the incidence of pre-eclampsia (2.0% [one case] and 14.5% [eight cases], respectively) and mRNA level of superoxide-dismutase, heme oxygenase-1, vascular endothelial growth factor receptor-1, endoglin and placental growth factor after supplementation. Conclusion: Supplementation of women with low antioxidant status with micronutrients containing antioxidants during early gestation might reduce the risk of pre-eclampsia.