The Hes gene family: repressors and oscillators that orchestrate embryogenesis
The Hes gene family: repressors and oscillators that orchestrate embryogenesis
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DOI：
10.1242/dev.000786
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发表时间：
2007-04-01
期刊：
影响因子：
4.6
通讯作者：
Kobayashi, Taeko
中科院分区：
文献类型：
--
作者：
Kageyama, Ryoichiro;Ohtsuka, Toshiyuki;Kobayashi, Taeko
胚胎发生涉及细胞增殖和分化的协调过程。哺乳动物he的基本螺旋-环-螺旋抑制基因在这些过程中发挥核心作用，通过维持祖细胞处于未分化状态和调节二元细胞的命运决定。他的基因也表现出振荡表达模式，并控制生物事件的时间，如体分割。he表达的许多方面都受到Notch信号的调控，Notch信号介导细胞间的通讯。本引物描述了Hes基因在一些发育过程中的多效性作用，旨在阐明基因网络在脊椎动物胚胎发生中的基本机制。
Embryogenesis involves orchestrated processes of cell proliferation and differentiation. The mammalian Hes basic helix-loop-helix repressor genes play central roles in these processes by maintaining progenitor cells in an undifferentiated state and by regulating binary cell fate decisions. Hes genes also display an oscillatory expression pattern and control the timing of biological events, such as somite segmentation. Many aspects of Hes expression are regulated by Notch signaling, which mediates cell-cell communication. This primer describes these pleiotropic roles of Hes genes in some developmental processes and aims to clarify the basic mechanism of how gene networks operate in vertebrate embryogenesis.