Autoimmune overlap syndromes
Autoimmune overlap syndromes
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自身免疫重叠综合征
DOI：
10.1053/jhep.2001.23316
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发表时间：
2001
期刊：
影响因子：
13.5
通讯作者：
J. Neuberger
中科院分区：
文献类型：
--
作者：
J. Woodward;J. Neuberger
Some patients present with features of an autoimmune liver condition that do not conform uniquely to any of the established criteria for the diagnosis of autoimmune hepatitis (AIH), primary biliary cirrhosis (PBC), or primary sclerosing cholangitis (PSC) (Fig. 1A). In many instances this is due to the presence of diagnostic characteristics of more than one of these diseases. Confusion, therefore, arises because of the inability to assign a single diagnosis to such patients; these conditions have been termed as overlap syndromes (Fig. 1B). The significance of these overlap syndromes remain unclear and there may be several explanations: (1) Patients with these presentations could be considered as having a disease that is distinct from either (Fig. 1C). (2) Such patients might be suffering from 2 conditions simultaneously. (3) The diagnostic boundaries of one disease include features of one or more of the other conditions so that while there is clinical, serologic, radiologic, or histologic overlap, there is no true overlap syndrome (Fig. 1D). We believe that the balance of evidence supports the third contention in the great majority of instances, and that the term “overlap syndrome” reflects the current imprecision in definition of the individual diseases, in part due to lack of clear understanding of their etiology.
影响因子：
158.5
作者：
VANDEWATER, J;COOPER, A;GERSHWIN, ME
通讯作者：
GERSHWIN, ME
影响因子：
6.2
作者：
Morabito, N;Crisafulli, A;Squadrito, F
通讯作者：
Squadrito, F