Hydrolysis of amides to carboxylic acids catalyzed by Nb2O5
Hydrolysis of amides to carboxylic acids catalyzed by Nb2O5
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DOI：
10.1039/d0cy02230f
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发表时间：
2021-03
影响因子：
5
通讯作者：
S. H. Siddiki;Md. Nurnobi Rashed;A. S. Touchy;Md. A. R. Jamil;Yuan Jing;Takashi Toyao;Z. Maeno;K. Shimizu
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文献类型：
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作者：
S. H. Siddiki;Md. Nurnobi Rashed;A. S. Touchy;Md. A. R. Jamil;Yuan Jing;Takashi Toyao;Z. Maeno;K. Shimizu
酰胺水解为羧酸是工业上重要的反应，但由于难以裂解共振稳定的酰胺 C-N 键，因此具有挑战性。在乙酰胺水解中检查了二十三种非均相和均相催化剂。结果表明，Nb2O5 是最有效的多相催化剂，乙酸收率最高。对一系列在不同温度下煅烧的 Nb2O5 催化剂进行了乙酰胺水解的表征和测试，以确定 Nb2O5 的晶相和表面性质对催化性能的影响。观察到的高催化性能主要归因于即使在碱性抑制剂（NH3 和 H2O）存在下路易斯酸位点也能轻松激活羰基键。催化研究表明该方法具有操作简单、催化剂可回收、无添加剂、无溶剂、底物范围广（>40例；分离收率高达95%）等合成优点。
Hydrolysis of amides to carboxylic acids is an industrially important reaction but is challenging due to the difficulty of cleaving the resonance stabilized amidic C–N bond. Twenty-three heterogeneous and homogenous catalysts were examined in the hydrolysis of acetamide. Results showed that Nb2O5 was the most effective heterogeneous catalyst with the greatest yield of acetic acid. A series of Nb2O5 catalysts calcined at various temperatures were characterized and tested in the hydrolysis of acetamide to determine the effects of crystal phase and surface properties of Nb2O5 on catalytic performance. The high catalytic performance observed was attributed mainly to the facile activation of the carbonyl bond by Lewis acid sites that function even in the presence of basic inhibitors (NH3 and H2O). The catalytic studies showed the synthetic advantages of the present method, such as simple operation, catalyst recyclability, additive free, solvent free, and wide substrate scope (>40 examples; up to 95% isolated yield).