Are children who are treated for asthma and seasonal allergic rhinitis disadvantaged in their educational attainment when acutely exposed to air pollution and pollen? A feasibility study
Are children who are treated for asthma and seasonal allergic rhinitis disadvantaged in their educational attainment when acutely exposed to air pollution and pollen? A feasibility study
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DOI：
10.23889/ijpds.v3i2.522
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发表时间：
2018-06
影响因子：
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通讯作者：
A. Mizen;J. Lyons;S. Rodgers;D. Berridge;A. Akbari;P. Wilkinson;Ai Milojevic;R. Doherty;L. Dearden;I. Lake;D. Carruthers;Sarah Strickland;A. Mavrogianni;G. Davies
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文献类型：
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作者：
A. Mizen;J. Lyons;S. Rodgers;D. Berridge;A. Akbari;P. Wilkinson;Ai Milojevic;R. Doherty;L. Dearden;I. Lake;D. Carruthers;Sarah Strickland;A. Mavrogianni;G. Davies
研究背景目前缺乏证据表明空气质量对有空气质量相关健康状况的人的认知有不良影响，这些在文献中没有广泛记载。教育程度作为认知的代表，可能会随着空气质量的改善而增加。在匿名的避风港内准备个人和家庭层面的相关环境和健康数据进行分析;分析我们研究调查的相关数据集：认知，呼吸道疾病和呼吸系统疾病（CORTEX）的影响。匿名的，常规收集的健康和教育数据与高空间分辨率的污染测量和每日花粉测量相关联，使用SAIL数据库对卡迪夫市的18，241名学生提供重复的横断面队列（2009-2015年）。经过充分调整的多级线性回归分析研究了健康状况和/或空气质量之间的关联。队列、学校和个人水平的混杂因素均得到控制。我们希望使用个人水平的多地点每日暴露评估将有助于澄清交通的作用，并防止潜在的社区水平的混淆。研究还调查了空气质量对哮喘和/或严重过敏性鼻炎（SAR）治疗者和未治疗者教育程度变化的综合影响。哮喘与考试成绩无关（p=0.7）。然而，SAR与考试成绩呈正相关（p<0.001）。无论健康状况如何，暴露于空气污染与教育程度呈负相关。结论无论健康状况如何，空气质量与受教育程度呈负相关。寻求治疗的行为可以解释SAR和教育程度之间的正相关。为了更准确地反映健康状况，应调查不受寻求治疗行为（如急诊入院）影响的健康结果。
BackgroundThere is a lack of evidence of the adverse effects which air quality has on cognition for people with air quality-related health conditions, these are not widely documented in the literature. Educational attainment, as a proxy for cognition, may increase with improved air quality. ObjectivesPrepare individual and household level linked environmental and health data for analysis within an anonymised safe haven; analyse the linked dataset for our study investigating: Cognition, Respiratory Tract illness and Effects of eXposure (CORTEX). MethodsAnonymised, routinely collected health and education data were linked with high spatial resolution pollution measurements and daily pollen measurements to provide repeated cross-sectional cohorts (2009-2015) on 18,241 pupils across the city of Cardiff, using the SAIL databank. A fully adjusted multilevel linear regression analysis examined associations between health status and/or air quality. Cohort, school and individual level confounders were controlled for. We hope that using individual-level multi-location daily exposure assessment will help to clarify the role of traffic and prevent potential community-level confounding. Combined effects of air quality on variation in educational attainment between those treated for asthma and/or Severe Allergic Rhinitis (SAR), and those not treated, was also investigated. FindingsAsthma was not associated with exam performance (p=0.7). However, SAR was positively associated with exam performance (p<0.001). Exposure to air pollution was negatively associated with educational attainment regardless of health status. ConclusionsIrrespective of health status, air quality was negatively associated with educational attainment. Treatment seeking behaviour may explain the positive association between SAR and educational attainment. For a more accurate reflection of health status, health outcomes not subject to treatment seeking behaviours, such as emergency hospital admission, should be investigated.