Fibrosing alveolitis, bronchiolitis obliterans, and sulfasalazine therapy.
Fibrosing alveolitis, bronchiolitis obliterans, and sulfasalazine therapy.
复制标题
纤维化肺泡炎、闭塞性细支气管炎和柳氮磺吡啶治疗。
作者：
T. Williams;L. Eidus;P. Thomas
一名溃疡性结肠炎患者在服用柳氮磺吡啶期间出现广泛的上区肺部疾病。肺功能检查显示进行性限制性和阻塞性疾病。肺活检显示闭塞性细支气管炎和慢性间质性肺炎或纤维化肺泡炎伴轻度嗜酸性粒细胞浸润。接受类固醇治疗后，患者病情好转。本文综述了与溃疡性结肠炎和柳氮磺吡啶相关的肺部疾病的文献。
A patient with ulcerative colitis had extensive upper zone pulmonary disease while taking sulfasalazine. Pulmonary function tests showed progressive restrictive and obstructive disease. Lung biopsy showed bronchiolitis obliterans and chronic interstitial pneumonia or fibrosing alveolitis with a mild eosinophilic infiltrate. The patient improved after receiving steroid therapy. A review of the literature of lung disease related to ulcerative colitis and sulfasalazine is presented.