MAMMARY CANCER INDUCED BY A SINGLE FEEDING OF POLYNUCLEAR HYDROCARBONS, AND ITS SUPPRESSION
MAMMARY CANCER INDUCED BY A SINGLE FEEDING OF POLYNUCLEAR HYDROCARBONS, AND ITS SUPPRESSION
复制标题
DOI：
10.1038/189204a0
复制
发表时间：
1961-01-01
期刊：
影响因子：
64.8
通讯作者：
GRAND, LC
中科院分区：
文献类型：
--
作者：
HUGGINS, C;BRILLANTES, FP;GRAND, LC
在我们的大鼠群体中，在大约20,000只不到8个月的未经治疗的雌性大鼠中观察到了两种“自发的”r乳腺癌。但在这种品系中，良性乳腺肿瘤在衰老时非常频繁地发生“。单次投喂3-MC(100MGM.)100只50-65日龄雌性大鼠连续10次致癌，20只雄性大鼠未观察到肿瘤。大鼠体重下降(总体重减少10-15克)。48小时。所有雌性大鼠均发生乳腺癌，其中2只发生外耳道附近皮脂腺鳞状细胞癌，未发现其他肿瘤。最早的乳腺癌是在第31天通过触诊发现的，最后一次是在130天。但在10只大鼠的腹股沟乳腺连续切片中，一次喂饲3-MC 14天后，镜检发现其中两个腺体有癌。皮脂腺鳞癌分别出现在第109天和第121天。
at necropsy when the total number of visible tumours (‘active centres") was counted. In our rat colony two “spontaneous' rmammary cancers have been observed among about 20,000 untreated female rats less than eight months of age. But benign mammary tumours occur very frequently in this strain in senescence".3-Methylcholanthrene. A single feeding of 3-MC (100 mgm.) induced cancer in 100 female rats, aged 50–65 days, in 10 consecutive series; no tumours were observed in 20 males treated similarly. The rats suffered a decline in body-weight (total loss 10–15 gm.) for 48 hr. after the feeding, but a gain in weight was observed on day 3. In these series o females, mammary cancer was observed in every rat and squamous carcinoma of sebaceous glands adjacent to the external auditory canal in two of them; no other tumours were found. The earliest mammary cancer was detected by palpation on day 31, and the last was observed on day 130. But in serial histo-logical sections of the inguinal mammary glands o 10 rats, 14 days after a single feeding of 3-MC, carcinomata were found in two of the glands on microscopic examination. The squamous carcinomata of sebaceous glands appeared, respectively, on days 109 and 121.