ACTION OF MUSCULAR WORK ON TRANSFER OF SUGARS ACROSS CELL BARRIERS - COMPARISON WITH ACTION OF INSULIN
ACTION OF MUSCULAR WORK ON TRANSFER OF SUGARS ACROSS CELL BARRIERS - COMPARISON WITH ACTION OF INSULIN
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DOI：
10.1152/ajplegacy.1953.173.2.212
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发表时间：
1953-01-01
影响因子：
--
通讯作者：
LEVINE, R
中科院分区：
文献类型：
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作者：
GOLDSTEIN, MS;MULLICK, V;LEVINE, R
众所周知，肌肉运动会增加组织对葡萄糖的吸收率。在肾切除的动物中，组织不能利用各种糖，包括葡萄糖的异构体。在这样的期望下。条件肌肉工作促进细胞进入的一些这些糖，尽管缺乏利用。这构成了一种与作者提出的胰岛素作用类似的现象，即，促进某些糖穿过细胞表面屏障的主要作用。正如胰岛素的情况一样，功促进在碳1、2和3处具有与D-葡萄糖相同化学构型的糖进入细胞。这种肌肉作功的作用不依赖于胰岛素，在去胰化的胰腺中表现出来。局部肌肉收缩的作用是促进糖进入全身水分，似乎是由体液机制运作。因此，假设胰岛素和收缩骨骼肌的体液产物都可以激活某些类型的糖跨越细胞表面屏障的转移机制。
Muscular work is known to increase the rate of uptake of glucose by tissues. In the eviscerated-nephrectomized animal the tissues are unable to utilize various sugars including isomers of glucose. Under such exptl. conditions muscular work promotes cellular entry of some of these sugars despite the absence of utilization. This constitutes a phenomenon parallel to that proposed by the authors for the action of insulin, i.e., a primary action on facilitating transfer of certain sugars across cell surface barriers. Just as in the case of insulin, work pro- motes cellular entry of sugars possessing the same chemical configuration as D-glucose at carbons 1, 2 and 3. This action of muscular work is independent of insulin and is exhibited in the depancreatized prepn. Local muscular contraction acts to facilitate sugar entry into total body water and appears to be operating by a humoral mechanism. It is thus postulated that both insulin and a humoral product of contracting skeletal muscle can activate a transfer mechanism for certain types of sugars across cell surface barriers.