TRIGGERING AND EXACERBATION OF AUTOIMMUNE ARTHRITIS BY THE MYCOPLASMA-ARTHRITIDIS SUPERANTIGEN MAM
TRIGGERING AND EXACERBATION OF AUTOIMMUNE ARTHRITIS BY THE MYCOPLASMA-ARTHRITIDIS SUPERANTIGEN MAM
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DOI：
10.1002/art.1780360717
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发表时间：
1993-07-01
影响因子：
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通讯作者：
GRIFFITHS, MM
中科院分区：
文献类型：
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作者：
COLE, BC;GRIFFITHS, MM
客观的。据推测，超级抗原可能通过激活自身反应性 T 细胞或诱导自身抗体，在人类风湿性疾病中发挥作用。关节炎支原体超抗原 MAM 源自天然存在的小鼠关节炎支原体，它使用小鼠 T 细胞受体 (TCR) 的某些 Vbeta 链，这些链已被认为与小鼠胶原诱导的关节炎 (CIA) 相关。本研究旨在确定 MAM 是否影响猪 II 型胶原 (PII) 免疫介导的关节炎病程。方法。将 MAM 或磷酸盐缓冲盐水 (PBS) 局部或全身注射到从 CIA 恢复的小鼠或胶原蛋白免疫效果不佳的小鼠中。结果。与 PBS 不同，MAM 会导致 CIA 恢复小鼠的关节炎恶化。 MAM 还会引发 160 天前接受 PII 免疫效果不佳的小鼠关节炎发作。在 CIA 发病阶段注射 MAM 也会引发并增强给予低剂量 PII 的小鼠关节炎的严重程度。结论。 MAM 可以引发和加剧由 II 型胶原蛋白免疫诱导的小鼠自身免疫性关节炎。由于已发现携带与 MAM 使用的相同 Vbeta TCR 的 T 细胞构成类风湿性关节炎患者滑膜组织中活化细胞的主要部分，因此与 MAM 类似的超级抗原可能在这种人类疾病中发挥作用。
Objective. It has been postulated that superantigens might play a role in the human rheumatic diseases, by activation of self-reactive T cells or by induction of autoantibodies. The Mycoplasma arthritidis superantigen MAM, which is derived from a naturally occurring murine arthitogenic mycoplasma, uses certain Vbeta chains of the murine T cell receptor (TCR) that have been proposed to be involved in murine collagen-induced arthritis (CIA). The present study was designed to determine whether MAM influences the course of arthritis mediated by immunization with porcine type II collagen (PII).Methods. MAM or phosphate buffered saline (PBS) was injected locally or systemically into mice convalescing from CIA or mice suboptimally immunized with collagen.Results. In contrast to PBS, MAM caused an exacerbation of arthritis in mice that were recovering from CIA. MAM also triggered arthritis onset in mice that had been suboptimally immunized with PII up to 160 days previously. Injection of MAM during the onset phase of CIA also triggered and enhanced the severity of arthritis in mice given low doses of PII.Conclusion. MAM can both trigger and exacerbate murine autoimmune arthritis induced by immunization with type II collagen. Since T cells bearing the same Vbeta TCRs as are used by MAM have been found to comprise a major portion of the activated cells in the synovial tissue of patients with rheumatoid arthritis, it is possible that superantigens similar to MAM may play a role in this human disease.