Iron(II)-catalyzed asymmetric intramolecular olefin aminochlorination using chloride ion.
Iron(II)-catalyzed asymmetric intramolecular olefin aminochlorination using chloride ion.
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DOI：
10.1039/c5sc00221d
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发表时间：
2015-05-01
期刊：
影响因子：
8.4
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Zhu CL;Tian JS;Gu ZY;Xing GW;Xu H
我们报告了一种铁催化的内烯烃的不对称氨氯化方法，它容忍与现有方法不相容的有价值的烯烃。报道了铁催化的烯烃分子内胺氯化反应（ee高达92%，dr高达15：1）。在该反应中，官能化的羟胺和氯离子分别用作氮源和氯源。这种新方法容许一系列合成有价值的内烯烃，这些内烯烃都与现有的不对称烯烃氨氯化方法不相容。
We report an iron-catalyzed asymmetric aminochlorination method for internal olefins; it tolerates valuable olefins that are incompatible with existing methods. An iron-catalyzed enantioselective and diastereoselective intramolecular olefin aminochlorination reaction is reported (ee up to 92%, dr up to 15 : 1). In this reaction, a functionalized hydroxylamine and chloride ion are utilized as nitrogen and chlorine sources, respectively. This new method tolerates a range of synthetically valuable internal olefins that are all incompatible with existing asymmetric olefin aminochlorination methods.