Profiles of precentral and postcentral cortical mean thicknesses in individual subjects over acute and subacute time-scales.
Profiles of precentral and postcentral cortical mean thicknesses in individual subjects over acute and subacute time-scales.
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DOI：
10.1093/cercor/bhp226
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发表时间：
2010-07
期刊：
影响因子：
3.7
通讯作者：
Xin Wang;Mischka Gerken;M. Dennis;R. Mooney;J. Kane;S. Khuder;Hong Xie;W. Bauer;A. Apkarian;J. Wall
中科院分区：
文献类型：
--
作者：
Xin Wang;Mischka Gerken;M. Dennis;R. Mooney;J. Kane;S. Khuder;Hong Xie;W. Bauer;A. Apkarian;J. Wall
人的中枢前和中枢后皮质区相互作用产生感觉运动功能。最近的影像学研究表明，由于衰老、疾病和其他因素，个体的中枢前和中枢后皮层厚度在数年和数十年的时间尺度上有所不同。相比之下，人们对这些区域的厚度在几分钟和几周的时间尺度上是如何变化的了解很少。本研究使用纵向磁共振成像（MRI）和计算形态测量方法对5名健康受试者进行研究，以评估这些区域的平均厚度以及平均厚度在个体受试者中在几分钟和几周内的半球内和半球间关系。在每个个体中，这些时间内的绝对厚度差异很小，并且在中心前（平均= 0.02-0.04 mm）和中心后（平均= 0.03-0.05 mm）区域相似。在这些时间里，每个人在这些区域的厚度上也有一致的半球内差异和半球间不对称或对称关系。研究结果为这些区域的个体皮质厚度变异性提供了新的认识，并提出了纵向厚度谱可以提供短时间尺度厚度变异性的基线定义的可能性，该定义可用于检测个体受试者水平中央前后厚度的急性和亚急性变化。
Human precentral and postcentral cortical areas interact to generate sensorimotor functions. Recent imaging work suggests that pre- and postcentral cortical thicknesses of an individual vary over time-scales of years and decades due to aging, disease, and other factors. In contrast, there is little understanding of how thicknesses of these areas vary in an individual over time-scales of minutes and weeks. This study used longitudinal magnetic resonance imaging (MRI) and computational morphometry approaches in 5 healthy subjects to assess how mean thicknesses, and intra- and interhemispheric relationships in mean thicknesses, of these areas vary in an individual subject over minutes and weeks. Within each individual, absolute differences in thicknesses over these times were small and similar in the precentral (mean = 0.02-0.04 mm) and postcentral (mean = 0.03-0.05 mm) areas. Each individual also had a consistent intrahemispheric disparity and interhemispheric asymmetrical or symmetrical relationship in thicknesses of these areas over these times. The results provide new understanding of within-individual cortical thickness variability in these areas and raise the possibility that longitudinal thickness profiling can provide a baseline definition of short time-scale thickness variability that can be used to detect acute and subacute changes in pre- and postcentral thicknesses at an individual subject level.