REGULATION OF SERUM 1-ALPHA,25-DIHYDROXYVITAMIN-D3 BY CALCIUM AND PHOSPHATE IN RAT
REGULATION OF SERUM 1-ALPHA,25-DIHYDROXYVITAMIN-D3 BY CALCIUM AND PHOSPHATE IN RAT
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DOI：
10.1126/science.1188357
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发表时间：
1975-01-01
期刊：
影响因子：
56.9
通讯作者：
BAYLINK, DJ
中科院分区：
文献类型：
--
作者：
HUGHES, MR;BRUMBAUGH, PF;BAYLINK, DJ
采用一种新的放射受体测定法定量低钙或低磷饮食大鼠血清1α，25-二羟基维生素d3浓度的变化。任何一种离子的低可用性都会导致1α，25-二羟基维生素D3循环浓度增加五倍。钙缺乏时1α，25-二羟基维生素d3浓度的增强依赖于甲状旁腺或甲状腺（或两者）的存在，表明这种作用是由甲状旁腺激素介导的。相反，对磷酸盐缺乏的反应与这些腺体无关，可能是由于低血清磷酸盐浓度或与磷酸盐消耗有关的某些因素对肾脏合成1α，25-二羟基维生素d3激素的作用。
A new radioreceptor assay was used to quantify changes in serum concentration of 1α,25-dihydroxyvitamin D3in rats with low calcium or low phosphate diets. Low availability of either ion elicits a fivefold increase in the circulating concentration of 1α,25-dihydroxyvitamin D3. The enhancement of 1α,25-dihydroxyvitamin D3concentration in response to calcium deficiency is dependent on the presence of the parathyroid or thyroid glands (or both), suggesting that this effect is mediated by parathyroid hormone. In contrast, the response to phosphate deficiency is independent of these glands and may result from an action of low serum phosphate concentration or some factor associated with phosphate depletion on the renal synthesis of the 1α,25-dihydroxyvitamin D3hormone.