FIBRINOGEN AND RISK OF CARDIOVASCULAR-DISEASE - THE FRAMINGHAM-STUDY
FIBRINOGEN AND RISK OF CARDIOVASCULAR-DISEASE - THE FRAMINGHAM-STUDY
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DOI：
10.1001/jama.258.9.1183
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发表时间：
1987-09-04
影响因子：
120.7
通讯作者：
DAGOSTINO, RB
中科院分区：
文献类型：
--
作者：
KANNEL, WB;WOLF, PA;DAGOSTINO, RB
在弗雷明汉研究的第十次两年一次的检查中，1315名无心血管疾病的参与者测量了纤维蛋白原水平。在随后的12年里，165名男性和147名女性患上了心血管疾病。无论男女，心血管疾病的风险与先前纤维蛋白原值高于1.3至7.0 g/L（126至696 mg/dL）范围呈正相关。随着年龄的增长，风险的大小在女性中降低，但在男性中没有。纤维蛋白原水平与冠心病风险也有显著相关性。在这里，风险的大小随着年龄的增长而减小，同样只在女性中。随着纤维蛋白原水平的升高，卒中风险逐渐增加。男人有，女人没有。纤维蛋白原值作为一个单独的变量，对心血管CP疾病的影响与血压、红细胞压积、肥胖、吸烟和糖尿病等主要危险因素相当。纤维蛋白原值也与这些危险因素显著相关。在多变量分析中，考虑到所有这些因素，纤维蛋白原水平仍然与男性心血管疾病的发病率显著相关，而在女性中则不显著。对于冠心病，纤维蛋白原水平对男性和女性都很重要。纤维原水平升高是心血管疾病的预测因子，应添加到心血管危险因素档案中。
During the tenth biennial examination of the Framingham Study, 1315 participants who were free of cardiovascular disease had fibrinogen levels measured. During the ensuing 12 years, cardiovascular disease developed in 165 men and 147 women. For both sexes, the risk of cardiovascular disease was correlated positively to antecedent fibrinogen values higher than the 1.3 to 7.0 g/L (126 to 696 mg/dL) range. The magnitude of the risk diminished with advancing age in women but not in men. Risk for coronary heart disease also was significantly related to fibrinogen level. Here, the magnitude of risk displayed diminishing impact with age, again only in women. Risk of stroke increased progressively with fibrinogen level. In men but not in women. The impact of fibrinogen value, considered as a separate variable, on cardiovascular CP disease was comparable with the major risk factors, such as blood pressure, hematocrit, adiposity, cigarette smoking, and diabetes. Fibrinogen values were also significantly related to these risk factors. Taking all these into account in a multivariate analysis, fibrinogen level was still significantly related to the incidence of cardiovascular disease in men and marginally significant in women. For coronary heart disease, the fibrinogen level was significant for both men and women. Elevated fibriongen level is a predictor of cardiovascular disease that should be added to the cardiovascular risk factor profile.