NRF2 and the Moirai: Life and Death Decisions on Cell Fates.
NRF2 and the Moirai: Life and Death Decisions on Cell Fates.
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DOI：
10.1089/ars.2022.0200
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发表时间：
2023-03
影响因子：
6.6
通讯作者：
中科院分区：
文献类型：
--
作者：
转录因子NRF 2（NF-E2-related factor 2）通过激活NRF 2靶基因的转录程序而作为细胞防御系统的主调节因子发挥重要作用，所述NRF 2靶基因编码与细胞氧化还原平衡和异生物质解毒相关的多种酶。全面的转录分析继续揭示NRF 2靶基因的范围不断扩大，证明了NRF 2生物特征的复杂性和多样性，超出了其典型的细胞保护作用。越来越多的证据表明，NRF 2通过影响细胞生命周期三个主要阶段中细胞转变的关键过程（即，细胞出生、细胞分化和细胞死亡）。NRF 2信号传导通过广泛的NRF 2靶基因整合到该调节程序中，这些基因涵盖经典功能和操纵细胞命运途径的基因。一个单一的重点NRF 2信号解剖其行动限制了深入了解其与细胞命运决定的分子机制的交叉。由NRF 2调控的下游通路的补偿性反应需要进一步探索，NRF 2由多种转录因子和多因子信号串扰执行。需要使用优化的体内模型和积极参与的总体方法来探测广泛途径的相互作用的进一步研究，以研究NRF 2信号传导作为细胞命运调控域内大型网络的一部分的性质和能力。抗氧化剂。氧化还原信号。38，684-708。
The transcription factor NRF2 (NF-E2-related factor 2) plays an important role as a master regulator of the cellular defense system by activating transcriptional programs of NRF2 target genes encoding multiple enzymes related to cellular redox balance and xenobiotic detoxication. Comprehensive transcriptional analyses continue to reveal an ever-broadening range of NRF2 target genes, demonstrating the sophistication and diversification of NRF2 biological signatures beyond its canonical cytoprotective roles. Accumulating evidence indicates that NRF2 has a strong association with the regulation of cell fates by influencing key processes of cellular transitions in the three major phases of the life cycle of the cell (i.e., cell birth, cell differentiation, and cell death). The molecular integration of NRF2 signaling into this regulatory program occurs through a wide range of NRF2 target genes encompassing canonical functions and those manipulating cell fate pathways. A singular focus on NRF2 signaling for dissecting its actions limits in-depth understanding of its intersection with the molecular machinery of cell fate determinations. Compensatory responses of downstream pathways governed by NRF2 executed by a variety of transcription factors and multifactorial signaling crosstalk require further exploration. Further investigations using optimized in vivo models and active engagement of overarching approaches to probe the interplay of widespread pathways are needed to study the properties and capabilities of NRF2 signaling as a part of a large network within the cell fate regulatory domain. Antioxid. Redox Signal. 38, 684–708.
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影响因子：
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作者：
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发表时间：
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影响因子：
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作者：
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