Quantification of myocardial blood flow.
Quantification of myocardial blood flow.
复制标题
心肌血流量的量化。
DOI：
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发表时间：
1992
影响因子：
9.3
通讯作者：
G. T. Smith
中科院分区：
文献类型：
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作者：
G. T. Smith
致编辑：我想指出Kuhle（1）在第38届核医学学会年会论文集上发表的摘要中的一个错误。在~ 3 N-NH_3定量心肌血流量（MBF）的二比较模型中，K_1 = 10.607exp（-1.25/MBF）的关系式是不正确的。相反，这是13 N-氨的首过心肌提取分数的方程（2）。两室之间的正向速率常数可表示为KI = E.MBF/（1-E），其可简化为K_1 = MBF。[ 1.65exp（1.25/MBF）1 ]，其中E为浸提分数。奇怪的是，我在提交给第35届年会的摘要中犯了同样的错误（3），该摘要使用不同的动物数据集描述了心肌t3 N-氨动力学的相同模型。这一错误后来在会议的海报展示中得到纠正。自我最初的摘要以来，该模型已经使用合成数据进行了验证，以解决由于假设的分布容积、逆转速率常数（k2）和噪声（4）的不准确性而导致的MBF计算值的错误。此外，在我的原始摘要中以及在使用运动和潘生丁负荷的患者中，通过~ 3 Nammonia PET扫描证实了该模型的临床实用性（3，5，6）。还描述了基于该模型估计k2和内部心肌剂量测定的方法（7，8）。最后，报告了神经网络分析和双比较模型计算的MBF的比较（9）。关于神经网络与模型相关性的进一步工作被SNM 1991科学计划委员会拒绝。祝贺Kuhle博士将图像数据重新切片为短轴投影的想法，这显然是一位年轻研究者的灵感。我期待着第39届核医学学会年会，这样我们就可以“再玩一次，山姆”（10）。
TO THE EDITOR: I would like to point out an error in the abstract by Kuhle (1) published in the Proceedings of the 38th Annual Meeting of the Society of Nuclear Medicine. In the twocompar tment model for quantification of myocardial blood flow (MBF) using ~3N-ammonia, the relationship K1 = 10 .607exp(-1.25/MBF) is incorrect. Rather, this is the equation for the first-pass myocardial extraction fraction of 13N-ammonia (2). The forward rate constant between the two compartments can be shown to be KI = E.MBF/(1-E), which reduces to K1 = MBF. [ 1.65exp( 1.25/MBF)1 ], where E is the extraction fraction. Curiously, I made the same error in my abstract submitted to the 35th annual meeting (3), which described the identical model for myocardial t 3N-ammonia kinetics using a different set of animal data. The error was subsequently corrected in the poster presentation at the meeting. Since my original abstract, the model has been validated using synthetic data to address errors in the calculated value of MBF due to inaccuracies in the assumed volume of distribution, reverse rate constant (k2), and noise (4). In addition, the clinical utility of the model was demonstrated both in my original abstract and in patients both using exercise and dipyridamole stress with ~3Nammonia PET scanning (3,5,6). Methods to estimate k2 and internal myocardial dosimetry based on the model have also been described (7,8). Finally, comparison of calculated MBF from neural network analysis and from the two-compar tment model have been reported (9). Further work on neural network correlation with the model was rejected by the SNM 1991 Scientific Program Committee. Congratulations to Dr. Kuhle on his idea to reslice the image data into short-axis projections, obviously the inspiration of a Young Investigator. I look forward to the 39th Annual Society of Nuclear Medicine Meeting so we can "Play It Again, Sam" (10).