Dendritic reorganization of an identified neuron during metamorphosis of the moth Manduca sexta: the influence of interactions with the periphery.

Dendritic reorganization of an identified neuron during metamorphosis of the moth Manduca sexta: the influence of interactions with the periphery.
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Manduca sexta 蛾变态过程中已识别神经元的树突重组:与周围相互作用的影响。

DOI:
10.1002/neu.480240102
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发表时间:
1993
期刊:
Journal of neurobiology
影响因子:
--
通讯作者:
Levine,RB
Levine,RB
中科院分区:
--
文献类型:
--
作者:
Kent,KS;Levine,RB

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在蛾的变态过程中,天蛾,一个确定的腿运动神经元,股伸肌运动神经元(FeExt MN)经历了戏剧性的重组。幼虫树突占据两个不同的区域neurology,一个在腿外侧neurology和第二个在背内侧neurology。成年树突占据了更大的体积外侧腿神经节,但不延伸到背内侧区的神经节。成年树突的形态是通过极端的树突退化,然后是广泛的树突生长获得的。在幼虫生命结束时,MN树突开始退化,但最戏剧性的损失树突发生在3天后化蛹,这样只有少数稀疏的树突保留在腿神经节的外侧区域。在随后的几天内发生广泛的树突状生长,使得MN在化蛹后12至14天之间获得成虫样形态。树突重塑的这个基本过程并不依赖于成人腿的存在,这表明与新的靶肌肉的接触和来自新的腿感觉神经元的输入对于触发树突的变化都是不必要的。MN树突在成人的最终分布,但是,改变时,成人腿是缺席的,这表明线索从成人腿参与定向或塑造的MN树突的生长到特定区域的神经元。John Wiley & Sons,Inc.
During metamorphosis of the moth,Manduca sexta, an identified leg motor neuron, the femoral extensor motor neuron (FeExt MN) undergoes dramatic reorganization. Larval dendrites occupy two distinct regions of neuropil, one in the lateral leg neuropil and a second in dorsomedial neuropil. Adult dendrites occupy a greater volume of lateral leg neuropil but do not extend to the dorsomedial region of the ganglion. The adult dendritic morphology is acquired by extreme dendritic regression followed by extensive dendritic growth. Towards the end of larval life, MN dendrites begin to regress, but the most dramatic loss of dendrites occurs in the 3 days following pupation, such that only a few sparse dendrites are retained in the lateral region of leg neuropil. Extensive dendritic growth occurs over the subsequent days such that the MN acquires an adult‐like morphology between 12 and 14 days after pupation. This basic process of dendritic remodeling is not dependent upon the presence of the adult leg, suggesting that neither contact with the new target muscle nor inputs from new leg sensory neurons are necessary for triggering dendritic changes. The final distribution of MN dendrites in the adult, however, is altered when the adult leg is absent, suggesting that cues from the adult leg are involved in directing or shaping the growth of MN dendrites to specific regions of neuropil. © 1993 John Wiley & Sons, Inc.
类固醇激素和神经输入在控制天蛾天蛾中已识别的神经元死亡方面可能存在相互作用。
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影响因子: --
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