An adrenomedullin (ADM) fragment retains the systemic vasodilator activity of human ADM.
An adrenomedullin (ADM) fragment retains the systemic vasodilator activity of human ADM.
复制标题
肾上腺髓质素 (ADM) 片段保留了人 ADM 的全身血管舒张活性。
DOI：
10.1016/0024-3205(94)00844-2
复制
发表时间：
1994
期刊：
影响因子：
6.1
通讯作者：
Lippton,H
中科院分区：
文献类型：
--
作者：
Hao,Q;Chang,JK;Gharavi,H;Fortenberry,Y;Hyman,A;Lippton,H
本研究观察了新近发现的存在于正常人血浆中的人ADM及其片段人ADM 13-52对麻醉猫血流动力学的影响。静脉注射人ADM和人ADM 13-52以剂量依赖的方式降低体动脉压(SAP)。由于这两种多肽都不改变心输出量，因此SAP的降低反映了全身血管阻力的减少。猫对相同剂量的人ADM和人ADM 13-52的全身血管扩张反应相似。目前的研究表明，ADM的全身血管扩张活性是跨物种保守的。提示人ADM 13-52或与其结构相似的多肽可能在人体内介导ADM的血流动力学特性。由于心输出量和心率在ADM显著的全身血管降压反应中没有改变，激活ADM的血管扩张机制可能是临床治疗高血压疾病的一种替代治疗方法。
The present study was undertaken to investigate the effects of human ADM, a newly discovered peptide present in normal human plasma, as well as a fragment of human ADM, human ADM 13–52, on systemic hemodynamics in the anesthetized cat. Intravenous (iv) bolus injections of human ADM and human ADM 13–52 decreased systemic arterial pressure (SAP) in a dose-dependent manner. Since neither peptide altered cardiac output, the decreases in SAP reflect reductions in systemic vascular resistance. The systemic vasodilator responses to the same doses of human ADM and human ADM 13–52 in the cat were similar. The present study demonstrates the systemic vasodilator activity of ADM is conserved across species. The present data suggest that human ADM 13–52 or a peptide structurally similar to it may mediate the hemodynamic properties of ADM in vivo in man. Since cardiac output and heart rate were not altered during the marked systemic vasodepressor response to ADM, activation of the ADM vasodilator mechanism may represent a therapeutic alternative in the clinical management of hypertensive diseases.