A convenient method for the preparation of dl-5-methyltetrahydrofolic acid (dl-5-methyl-5,6,7,8-tetrahydropteroyl-L-monoglutamic acid).
A convenient method for the preparation of dl-5-methyltetrahydrofolic acid (dl-5-methyl-5,6,7,8-tetrahydropteroyl-L-monoglutamic acid).
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一种制备dl-5-甲基四氢叶酸（dl-5-甲基-5,6,7,8-四氢蝶酰基-L-单谷氨酸）的简便方法。
DOI：
10.1016/0003-2697(70)90122-3
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发表时间：
1970
影响因子：
2.9
通讯作者：
K. J. Saunders
中科院分区：
文献类型：
--
作者：
J. Blair;K. J. Saunders
采用叶酸(翼酰基-L-单谷氨酸)还原，再以硼氢化钠为还原剂，两步与甲醛还原缩合，不分离中间体四氢叶酸的方法，为大量制备dl-5-甲基四氢叶酸及其钙、钡盐提供了一种简便的方法。
The reduction of folic acid (pteroyl-l-monoglutamic acid) followed by reductive condensation with formaldehyde with sodium borohydride as reducing agent at both stages and without isolation of the intermediate tetrahydrofolic acid is used to provide a convenient method of preparing dl-5-methyltetrahydrofolic acid and its calcium and barium salts in quantity.