Effect of vitamin A and its derivatives on collagen production and chemotactic response of fibroblasts
Effect of vitamin A and its derivatives on collagen production and chemotactic response of fibroblasts
复制标题
维生素A及其衍生物对成纤维细胞胶原蛋白生成和趋化反应的影响
DOI：
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发表时间：
1984
影响因子：
10.3
通讯作者：
T. Krieg
中科院分区：
文献类型：
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作者：
R. Hein;Hartwig Mensing;Peter Müller;O. Braun;T. Krieg
将维生素A和其他几种类维生素A添加到成纤维细胞培养物中，以研究生化特性和细胞反应性的可能改变。随着维甲酸浓度从10 - 9增加到10 - 5 mol/l，细胞增殖受到抑制。非胶原蛋白的合成以及I型和III型胶原蛋白的产生减少。培养的肌腱成纤维细胞合成III型胶原的时间延迟。此外，在类维生素A（10−6至10−12 mol/l）存在下，成纤维细胞对成纤维细胞条件培养基的趋化反应显著降低。
Vitamin A and several other retinoids were added to fibroblast cultures in order to study possible alterations in biochemical properties and cellular responsiveness. The proliferation of cells was inhibited as the concentration of retinoids increased from 10‐9 to 10‐5mol/l. Synthesis of non‐collagenous proteins and production of both type I and type III collagen were decreased. The onset of type III collagen synthesis by tendon fibroblasts in culture was delayed. Furthermore, the chemotactic response of fibroblasts to fibroblast‐conditioned medium was markedly reduced in the presence of retinoids (10−6 to 10−12 mol/l).
不同恶性肿瘤的两种纤维肉瘤亚群的趋化反应性的比较。
DOI：
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发表时间：
1981
期刊：
The American journal of pathology
影响因子：
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作者：
Orr,FW;Varani,J;Delikatny,J;Jain,N;Ward,PA
通讯作者：
Ward,PA