Mitochondria, Aging, and Cellular Senescence: Implications for Scleroderma.
Mitochondria, Aging, and Cellular Senescence: Implications for Scleroderma.
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线粒体，衰老和细胞衰老：对硬皮病的影响。
DOI：
10.1007/s11926-020-00920-9
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发表时间：
2020-06-19
影响因子：
5
通讯作者：
Mora AL
中科院分区：
文献类型：
--
作者：
Bueno M;Papazoglou A;Valenzi E;Rojas M;Lafyatis R;Mora AL
系统性硬化症（SSc）是一种以血管损伤和纤维化为特征的罕见免疫介导的炎症性疾病，其病因仍不清楚。然而，不同的内在（遗传学）和外在（环境）因素在疾病的进展中发挥作用。本文就衰老、线粒体功能障碍和衰老在SSc中的作用作一综述。线粒体功能障碍和衰老与年龄相关的其他间质性肺病（ILD）（如特发性肺纤维化（IPF））易感性有关。SSc不被认为是一种与年龄相关的疾病，但确实显示出更高的心脏事件、纤维化和死亡率。我们提供了一个概述的作用，衰老，线粒体功能障碍和衰老的SSc的现状。需要进一步的工作来验证SSc中的这些途径中的一些;并且可以允许新的治疗干预，其集中于恢复线粒体稳态和慢性衰老细胞的靶向去除。
The etiology of systemic sclerosis (SSc), which is a rare immune-mediated inflammatory disease characterized by vascular damage and fibrosis, is still unknown. However, different intrinsic (genetics) and extrinsic (environmental) factors play a part in the progression of the disease. This review focuses on the role of aging, mitochondrial dysfunction and senescence in SSc. Mitochondrial dysfunction and senescence has been linked to the age-related susceptibility to other interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF). SSc is not regarded as an age-related disease, but does shows a higher incidence of cardiac events, fibrosis and mortality at older age. We provide an overview of the current status of the role of aging, mitochondrial dysfunction and senescence in SSc. Further work is needed to validate some of these pathways in SSc; and may allow for new therapeutic interventions focused on restoring mitochondrial homeostasis and the targeted removal of chronic- senescent cells.
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Toll样受体9可被内源线粒体DNA激活诱导足细胞凋亡
影响因子：
4.6
作者：
Bao W;Xia H;Liang Y;Ye Y;Lu Y;Xu X;Duan A;He J;Chen Z;Wu Y;Wang X;Zheng C;Liu Z;Shi S
通讯作者：
Shi S
DOI：
10.1084/jem.20151876
发表时间：
2016-05-02
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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通讯作者：
Pascual V
影响因子：
3.7
作者：
Bueno, Marta;Zank, Daniel;Mora, Ana L.
通讯作者：
Mora, Ana L.
影响因子：
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作者：
Akamata K;Wei J;Bhattacharyya M;Cheresh P;Bonner MY;Arbiser JL;Raparia K;Gupta MP;Kamp DW;Varga J
通讯作者：
Varga J
影响因子：
4.6
作者：
Jaeger, Veronika K.;Lebrecht, Dirk;Walker, Ulrich A.
通讯作者：
Walker, Ulrich A.