Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and cardiac troponin I.
Comparable detection of acute myocardial infarction by creatine kinase MB isoenzyme and cardiac troponin I.
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DOI：
10.1093/clinchem/40.7.1291
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发表时间：
1994-07
影响因子：
9.3
通讯作者：
Jesse E. Adams;Kenneth B. Schechtman;Yvonne Landt;J. Ladenson;A. S. Jaffe
中科院分区：
文献类型：
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作者：
Jesse E. Adams;Kenneth B. Schechtman;Yvonne Landt;J. Ladenson;A. S. Jaffe
虽然在某些情况下，心肌肌钙蛋白I （cTnI）的检测比肌酸激酶MB同工酶（MBCK）的检测更能检测心脏损伤，但其相对于MBCK检测心肌梗死的敏感性和特异性尚未确定。因此，我们前瞻性地研究了199名连续入住冠状动脉监护室的患者。测定所有样品的MBCK和cTnI质量值。188例疑似急性心肌缺血入院患者中，89例根据MBCK值模式诊断为急性心肌梗死。其中86例患者cTnI也增加（一致性，96.6%）；三个没有。在诊断为无梗死的患者中，5例入院前有不稳定型心绞痛和症状的患者cTnI升高，cTnI特异性为94.9%。受试者工作特征曲线分析表明，cTnI和MBCK对急性心肌梗死的诊断准确率在统计学上无显著差异。
Although measurement of cardiac troponin I (cTnI) is, in some situations, more specific for detection of cardiac injury than is measurement of the MB isoenzyme of creatine kinase (MBCK), its sensitivity and specificity relative to MBCK for detection of myocardial infarction has not been established. Accordingly, we studied prospectively 199 consecutive patients admitted to the coronary care unit. Values of MBCK and cTnI mass were determined in all samples. Of the 188 patients admitted with a suspicion of acute myocardial ischemia, 89 were diagnosed as having an acute myocardial infarction on the basis of the patterns of MBCK values. Eighty-six of these patients also had increased cTnI (concordance, 96.6%); three did not. Of the patients diagnosed as without infarction, five with unstable angina and symptoms in the day(s) prior to admission had increased cTnI, for a cTnI specificity of 94.9%. Receiver operating characteristic curve analysis indicated that cTnI and MBCK had statistically indistinguishable diagnostic accuracies for the detection of acute myocardial infarction.