Initial results of in vivo CT imaging of contrast agents using MPPC-based photon-counting CT
Initial results of in vivo CT imaging of contrast agents using MPPC-based photon-counting CT
复制标题
使用基于 MPPC 的光子计数 CT 进行对比剂体内 CT 成像的初步结果
DOI：
10.1016/j.nima.2022.167960
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Satoshi Shiota
中科院分区：
文献类型：
--
作者：
Daichi Sato;Makoto Arimoto;Kotaro Yoshiura;Tomoya Mizuno;Ko Aiga;Kairi Ishiguro;Takahiro Tomoda;Hiroki Kawashima;Satoshi Kobayashi;Kenichiro Okumura;Kazuhiro Murakami;Jun Kataoka;Takaya Toyoda;Mayu Sagisaka;Shinsuke Terazawa;Satoshi Shiota
X射线计算机断层扫描（CT）是现代医学中的一项重要技术，因为它可以对身体内部进行三维非破坏性观察。对比增强CT扫描广泛用于病变增强成像。然而，传统的X射线CT系统集成了所有的入射X射线信号，导致单色能量信息的采集和材料识别的阻碍以及造影剂浓度的定量评估。近来，光子计数CT（PC-CT）作为用于解决这些问题的新系统已经引起注意。PC-CT利用单个X射线光子的能量信息，能够识别目标材料。我们已经进行了演示结合的PC-CT系统，我们开发的快速闪烁器和多像素光子计数器。在这项研究中，我们报告的初步结果，在体内X射线CT成像与我们建立的PC-CT系统。我们将碘造影剂注射到小鼠体内并可视化造影剂的空间分布。随后，我们在多个能带中使用所获得的CT图像进行K边缘成像和浓度映射。所获得的图像显示成功的三维对比度增强和浓度地图的肾脏和膀胱的小鼠，这表明显着的潜力，这种硅光电倍增管为基础的PC-CT系统的临床应用。
X-ray computed tomography (CT) is an essential technology in modern medicine, as it enables three-dimensional non-destructive observation of the inside of the body. Contrast-enhanced CT scanning is widely performed for lesion-enhanced imaging. However, conventional X-ray CT systems integrate all incident X-ray signals, leading to the acquisition of monochromatic energy information and the prevention of material identification and quantitative evaluation of the concentration of contrast agents. Recently, photon counting CT (PC-CT) has been attracting attention as a new system for solving these problems. PC-CT utilizes the energy information of individual X-ray photons, enabling the identification of target materials. We have performed demonstrations combining the PC-CT system that we developed with fast scintillators and multi-pixel photon counters. In this study, we report on the initial results of in-vivo X-ray CT imaging with our established PC-CT system. We injected an iodine contrast agent into a mouse and visualized the spatial distribution of the contrast agent. Subsequently, we performed K-edge imaging and concentration mapping with the obtained CT images in multiple energy bands. The obtained images displayed successful three-dimensional contrast enhancement and a concentration map of the kidney and bladder in the mouse, indicating significant potential for the clinical application of this silicon photomultiplier-based PC-CT system.