Neuroendocrine mechanisms regulating food intake and body weight.
Neuroendocrine mechanisms regulating food intake and body weight.
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DOI：
10.1046/j.1467-789x.2000.00007.x
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发表时间：
2000-05-01
期刊：
影响因子：
--
通讯作者：
Schwartz, M W
中科院分区：
文献类型：
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作者：
McMinn, J E;Baskin, D G;Schwartz, M W
在肥胖研究领域，出现了两条独立的研究路线，探索调节食物摄入的机制：食物摄入的短期控制和能量平衡的中枢调节。前者研究进食过程中的饱腹感反应，由此源自肠道的饱腹感信号被转换成调节脑干中饱腹感通路的神经信号。这篇综述描述了一个神经解剖学为基础的模型，其中瘦素和胰岛素信号在下丘脑管理长期调节能量平衡，通过机制，与饱腹激素信号在脑干集成。这种整合的功能性结果是食物摄入的累积餐对餐调节，其在相对长的时间间隔内用于维持稳定的脂肪储存。我们的模型提供了一个背景下，控制食物摄入量和体重的神经内分泌机制的持续调查，可以探索，并有潜在的应用，我们目前的理解临床肥胖及其治疗。
In the field of obesity research, two separate lines of study have emerged which explore the mechanism by which food intake is regulated: short-term control of food intake, and the central regulation of energy balance. The former studies the satiety response during consumption of meals, whereby satiety signalling originating in the gut is transduced into a neural signal that modulates satiety pathways in the brainstem. This review describes a neuroanatomically based model in which leptin and insulin signalling in the hypothalamus governs long-term regulation of energy balance via mechanisms that are integrated with satiety hormone signalling in the brainstem. The functional outcome of this integration is a cumulative meal-to-meal regulation of food intake, that over relatively long intervals serves to maintain stable adipose stores. Our model provides a context within which continued investigation of neuroendocrine mechanisms that control food intake and body weight can be explored, and has potential application to our current understanding of clinical obesity and its treatment.