Prevalence of polycystic ovary syndrome in Chinese obese women of reproductive age with or without metabolic syndrome
Prevalence of polycystic ovary syndrome in Chinese obese women of reproductive age with or without metabolic syndrome
复制标题
中国肥胖育龄妇女伴或不伴代谢综合征的多囊卵巢综合征患病率
DOI：
10.1016/j.fertnstert.2016.12.029
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发表时间：
2017-04-01
影响因子：
6.7
通讯作者：
Hong, Jie
中科院分区：
文献类型：
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作者：
Liang, Peiwen;Xi, Liuqing;Hong, Jie
目的：比较代谢不健康肥胖（MUO）和代谢健康肥胖（MHO）育龄妇女多囊卵巢综合征（PCOS）的患病率和相关临床特征。设计：横断面临床研究。地点：三级医院。患者：我们研究了299名MUO和122名MHO中国妇女，她们的体重指数相匹配。代谢健康性肥胖定义为不存在一种以上代谢异常的肥胖。多囊卵巢综合征的诊断依据修订后的鹿特丹标准。干预措施：每例受试者均接受体格检查、实验室评估和妇科超声检查以诊断多囊卵巢综合征或代谢综合征（MetS）。主要结果测量：计算两组中多囊卵巢综合征的患病率。胰岛素抵抗通过胰岛素抵抗的稳态模型评估或通过Bergman最小模型得出的胰岛素敏感性指数来确定。结果：MUO组和BMI匹配的MHO组PCOS及其各组分的患病率无明显差异（分别为67.89%和66.96%）。在logistic回归分析中，在调整混杂因素后，MetS不能预测PCOS的存在。MHO组有较低的内脏脂肪组织，相对较高的胰岛素敏感性，和更好的β细胞功能，与MUO组相比，但有没有显着差异性激素（除游离T和性激素结合球蛋白）和超声表现之间的MHO和MUO women.Conclusions（S）：第一次，我们的研究结果表明，代谢综合征不增加额外的风险PCOS。此外，我们发现MUO和MHO在一定程度上与胰岛素抵抗有关。(C)2017年，美国生殖医学会（American Society for Reproductive Medicine）
Objective: To compare the prevalence of polycystic ovary syndrome (PCOS) and related clinical characteristics between metabolically unhealthy obese (MUO) and metabolically healthy obese (MHO) women of reproductive age.Design: Cross-sectional clinical study.Setting: Tertiary hospital.Patient(s): We studied 299 MUO and 122 MHO Chinese women matched on body mass index. Metabolically healthy obese was defined as obesity with no more than one metabolic abnormality. Diagnosis of PCOS was based on the revised Rotterdam criteria.Intervention(s): Each subject underwent physical examination, laboratory evaluation, and gynecologic ultrasound for a diagnosis of PCOS or metabolic syndrome (MetS).Main Outcome Measure(s): Prevalence of PCOS was calculated in both groups. Insulin resistance was determined by homeostasis model assessment of insulin resistance or by the insulin sensitivity index derived from Bergman's minimal model. Fat distribution was measured with computerized tomography scan.Result(s): Prevalence of PCOS and its components did not differ between MUO and BMI-matched MHO groups (67.89% and 66.96%, respectively). In logistic regression analysis, MetS did not predict the presence of PCOS after adjusting for confounding factors. The MHO group had lower visceral adipose tissue, relatively higher insulin sensitivity, and better beta-cell function, compared with those in the MUO group; but there were no significant differences in sex hormones (except for free T and sex hormone-binding globulin) and ultrasound manifestations between MHO and MUO women.Conclusion(s): For the first time, our findings suggest that MetS does not add additional risk for PCOS. In addition, we found that both MUO and MHO are associated with insulin resistance to some extent. (C) 2017 by American Society for Reproductive Medicine.