Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest
Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest
复制标题
DOI：
10.1101/gad.1509307
复制
发表时间：
2007-02-15
影响因子：
10.5
通讯作者：
Bronner-Fraser, Marianne
中科院分区：
文献类型：
--
作者：
Kee, Yun;Hwang, Byung Joon;Bronner-Fraser, Marianne
由于所有动物的迁移细胞都具有共同的特性，我们假设线虫和脊椎动物之间涉及细胞迁移的遗传网络可能是保守的。为了探索这一点，我们进行了比较基因组分析，以确定所需的两性特异性神经元（HSN）迁移在秀丽隐杆线虫脊椎动物的直系同源基因，然后检查他们的表达和功能的脊椎动物神经嵴。研究结果表明，在不同物种的长距离迁移中涉及的调节组分具有高度的保守性。虽然神经嵴是脊椎动物的创新，但研究结果表明，它的迁移特性是通过利用共同的脊椎动物-无脊椎动物祖先中已经存在的程序进化而来的。
Because migratory cells in all animals share common properties, we hypothesized that genetic networks involved in cell migration may be conserved between nematodes and vertebrates. To explore this, we performed comparative genomic analysis to identify vertebrate orthologs of genes required for hermaphrodite-specific neuron (HSN) migration in Caenoryhabditis elegans, and then examined their expression and function in the vertebrate neural crest. The results demonstrate high conservation of regulatory components involved in long-range migrations across diverse species. Although the neural crest is a vertebrate innovation, the results suggest that its migratory properties evolved by utilizing programs already present in the common vertebrate-invertebrate ancestor.