Orientation tuning of surround suppression in lateral geniculate nucleus and primary visual cortex of cat
Orientation tuning of surround suppression in lateral geniculate nucleus and primary visual cortex of cat
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DOI：
10.1016/j.neuroscience.2007.08.001
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发表时间：
2007-11-23
期刊：
影响因子：
3.3
通讯作者：
Sato, H.
中科院分区：
文献类型：
--
作者：
Naito, T.;Sadakane, O.;Sato, H.
我们先前提出，初级视觉皮层（V1）中细胞的响应的定向调谐环绕抑制主要是由细胞的膝状皮层输入减少引起的[Ozeki H，Sadakane 0，Akasaki T，Naito T，Shimegi S，Sato H（2004）猫初级视觉皮层中激发和抑制之间的关系，其基础是大小调谐和上下文响应调制。J Neurosci 24：1428-1438]。为了进一步验证这一假设，我们比较了麻醉猫外侧膝状体（LGN）和V1神经元之间的环绕抑制的方向强度和空间相位选择性，以及经典外感受野（ECRF）的空间范围。LGN中的经典外环绕抑制与经典感受野（CRF）和ECRF刺激之间的方向对比度和相对空间相位相一致。在72.6%的LGN神经元和66.7%的V1神经元中观察到显著的方向调谐环绕抑制。LGN中ECRF的取向选择性程度与V1中的相当;然而，LGN中ECRF的相对空间相位选择性的强度高于先前针对V1报道的强度[Akasaki T，Sato H，Yoshimura Y，Ozeki H，Shimegi S（2002）Suppressive effects of receptive field surround on neuronal activity in the cat primary visual cortex. Neurosci Res 43：207-220; DeAngelis GC，Freeman RD，Ohzawa 1（1994）猫初级视觉皮层中神经元的长度和宽度调节。J Neurophysiol 71：347-374]。在70%的LGN神经元，表现出显着的方向调谐外经典环绕抑制，有效的方向的抑制根据CRF刺激的方向的变化而变化，而其余的30%表现出固定的首选方向的抑制，无论CRF光栅的方向。这些结果表明，环绕抑制的基本属性，如方向和空间相位调谐，已经存在于猫LGN和减少的环绕抑制LGN的兴奋性输入的环绕抑制是在V1的环绕抑制的主要原因。皮质膝状体反馈可能进一步阐述LGN中环绕抑制的性质。(c)2007年IBRO。由爱思唯尔有限公司出版。保留所有权利。
We previously suggested that orientation-tuned surround suppression of responses of cells in the primary visual cortex (V1) is primarily caused by a decrease in geniculocortical input for the cell [Ozeki H, Sadakane 0, Akasaki T, Naito T, Shimegi S, Sato H (2004) Relationship between excitation and inhibition underlying size tuning and contextual response modulation in the cat primary visual cortex. J Neurosci 24:1428-1438]. To further test this hypothesis, we compared the strength of orientation and spatia phase selectivity of surround suppression, and the spatia: extent of the extraclassical receptive field (ECRF) between the lateral geniculate nucleus (LGN) and V1 neurons of anesthetized cats. Extraclassical surround suppression in the LGN was well tuned to orientation-contrast and relative spatial phase between the classical receptive field (CRF) and ECRF stimuli. Significant orientation-tuned surround suppression was observed in 72.6% of the LGN neurons and the 66.7% of the V1 neurons tested. The degree of orientation selectivity of ECRF in LGN was comparable to that in V1; however, the strength of the relative spatial phase selectivity of ECRF in LGN was higher than that previously reported for V1 [Akasaki T, Sato H, Yoshimura Y, Ozeki H, Shimegi S (2002) Suppressive effects of receptive field surround on neuronal activity in the cat primary visual cortex. Neurosci Res 43:207-220; DeAngelis GC, Freeman RD, Ohzawa 1 (1994) Length and width tuning of neurons in the cat's primary visual cortex. J Neurophysiol 71:347-374]. In 70% of the LGN neurons that exhibited significant orientation-tuned extraclassical surround suppression, the effective orientation of the suppression varied according to a change in the orientation of CRF stimulus, while the remaining 30% exhibited a fixed preferred orientation of the suppression regardless of the orientation of the CRF grating. These results suggest that the basic properties of surround suppression, such as orientation and spatial phase tuning, already exist in cat LGN and that a decrease of surround suppression in excitatory inputs from LGN by surround suppression is the primary cause of surround suppression in V1. Corticogeniculate feedback may further elaborate the properties of surround suppression in LGN. (c) 2007 IBRO. Published by Elsevier Ltd. All rights reserved.