The Development and Psychometric Validation of the Central Sensitization Inventory
The Development and Psychometric Validation of the Central Sensitization Inventory
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DOI：
10.1111/j.1533-2500.2011.00493.x
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发表时间：
2012-04-01
期刊：
影响因子：
2.6
通讯作者：
Gatchel, Robert J.
中科院分区：
文献类型：
--
作者：
Mayer, Tom G.;Neblett, Randy;Gatchel, Robert J.
中枢致敏（CS）已被提出作为一种常见的病理生理机制来解释相关综合征，而这些综合征无法找到特定的有机原因。中枢性敏感综合征（CSS）一词被用来描述这些与中枢敏感综合征相关的鲜为人知的疾病。本研究的目的是制定中枢致敏量表（CSI），确定与css相关的关键症状，并量化这些症状的程度。然后评估CSI的效用，以区分可能具有不同程度CS损伤的不同类型的慢性疼痛患者。研究1显示CSI在一组规范被试中具有较强的心理测量特性（测试信度= 0.817;cronbach alpha = 0.879）。因子分析（包括规范性和慢性疼痛受试者）得出4个主要因素（均与躯体和情绪症状相关），占数据集中方差的53.4%。在研究2中，CSI分为4组：纤维肌痛（FM）组；无FM的慢性广泛性疼痛；与工作相关的区域性慢性腰痛（CLBP）；和规范对照组。分析显示，FM患者的CSI评分最高，正常人群最低（P < 0.05）。分析还表明，先前诊断的css和相关疾病的患病率在FM组最高，在规范组最低（P < 0.001）。综上所述，这两项研究证明了CSI在评估慢性疼痛人群中cs相关临床症状时的心理测量强度、临床实用性和初始结构效度。？
Central sensitization (CS) has been proposed as a common pathophysiological mechanism to explain related syndromes for which no specific organic cause can be found. The term central sensitivity syndrome (CSS) has been proposed to describe these poorly understood disorders related to CS. The goal of this investigation was to develop the Central Sensitization Inventory (CSI), which identifies key symptoms associated with CSSs and quantifies the degree of these symptoms. The utility of the CSI, to differentiate among different types of chronic pain patients who presumably have different levels of CS impairment, was then evaluated. Study 1 demonstrated strong psychometric properties (testretest reliability = 0.817; Cronbachs alpha = 0.879) of the CSI in a cohort of normative subjects. A factor analysis (including both normative and chronic pain subjects) yielded 4 major factors (all related to somatic and emotional symptoms), accounting for 53.4% of the variance in the dataset. In Study 2, the CSI was administered to 4 groups: fibromyalgia (FM); chronic widespread pain without FM; work-related regional chronic low back pain (CLBP); and normative control group. Analyses revealed that the patients with FM reported the highest CSI scores and the normative population the lowest (P < 0.05). Analyses also demonstrated that the prevalence of previously diagnosed CSSs and related disorders was highest in the FM group and lowest in the normative group (P < 0.001). Taken together, these 2 studies demonstrate the psychometric strength, clinical utility, and the initial construct validity of the CSI in evaluating CS-related clinical symptoms in chronic pain populations. ?