Neoplasms in persons treated with x-rays in infancy: fourth survey in 20 years.
Neoplasms in persons treated with x-rays in infancy: fourth survey in 20 years.
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婴儿期接受 X 射线治疗的人的肿瘤：20 年来的第四次调查。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
W. Ames
中科院分区：
文献类型：
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作者：
L. Hempelmann;W. Hall;M. Phillips;R. A. Cooper;W. Ames
通过对2,872名在婴儿期接受过x射线治疗的年轻人及其5,005名未接受过x射线治疗的兄弟姐妹进行邮件调查，确定了肿瘤疾病的发病率。新诊断的良性和恶性肿瘤在受辐射受试者中出现的频率高于他们的兄弟姐妹或纽约州北部年龄和性别匹配的一般人群。只有甲状腺肿瘤发生的数量足以统计分析性别、年龄、剂量和高危组（亚组C）对发病率的影响。甲状腺癌比良性肿瘤发展得更早，尤其是男孩；较小剂量后出现良性甲状腺肿，主要见于女性。女性患甲状腺癌的风险比男性高——所有年龄段的女性是男性的2.3倍，年轻人是男性的5倍。除年轻成年女性外，没有明显的年龄效应。癌症（但不包括良性甲状腺肿）的风险与甲状腺剂量成正比，整个辐照人群的线性风险系数为2.5/年/百万人暴露于1拉德，而C亚组的线性风险系数为4.0。C亚组中甲状腺癌的高风险可能是犹太人比例高的结果，他们的风险比非犹太人高3.4倍。年轻成年犹太女性患病风险增加了17倍。一个偶然的观察结果是，在辐照人群中，哮喘和具有异常免疫特征的罕见疾病的发病率明显增加。
The incidence of neoplastic disease was determined by a mail survey of 2,872 young adults given X-ray treatments in infancy and of their 5,005 nonirradiated siblings. Newly diagnosed benign and malignant neoplasms appeared more frequently in the irradiated subjects than in their siblings or the age- and sex-matched general population of upstate New York. Only thyroid neoplasms occurred in sufficient numbers to permit statistical analysis for the effects on incidence of sex, age, and dose, and of being in a high-risk group (sub-group C). Thyroid cancers developed earlier in life than did benign neoplasms, especially in boys; benign goiters occurred after smaller doses, predominantly in females. Females had a greater risk of developing thyroid cancer than males--2,3 times for females of all ages and 5 times for young adults. Except for young adult females, there was no definite age effect. The risk of cancer (but not of benign goiter) was proportional to the thyroid dose, with a linear risk coefficient of 2.5/year/million people exposed to 1 rad for the entire irradiated population and 4.0 for subgroup C. The high risk of thyroid cancer in subgroup C may be the result of the high percentage of Jews, who had a 3.4-fold greater risk than non-Jews. Young adult Jewish females had a 17-fold increased risk. An incidental observation was an apparent increased incidence of asthma and rare diseases with abnormal immunologic features in the irradiated population.