CHEMICAL-CONSTITUENTS OF AMARYLLIDACEAE .26. THE ROLE OF UNGEREMINE IN THE GROWTH-INHIBITING AND CYTO-TOXIC EFFECTS OF LYCORINE - EVIDENCE AND SPECULATION
CHEMICAL-CONSTITUENTS OF AMARYLLIDACEAE .26. THE ROLE OF UNGEREMINE IN THE GROWTH-INHIBITING AND CYTO-TOXIC EFFECTS OF LYCORINE - EVIDENCE AND SPECULATION
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DOI：
10.1055/s-2006-962364
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发表时间：
1988-04-01
期刊：
影响因子：
2.7
通讯作者：
CHATTOPADHYAY, S
中科院分区：
文献类型：
--
作者：
GHOSAL, S;SINGH, SK;CHATTOPADHYAY, S
本文评估了石蒜碱(1)的天然代谢物——龙生胺(2)在石蒜碱1的生长抑制和细胞毒性作用中的作用。Ungeremine对10种细菌分离株具有明显的抗菌作用，并显著抑制小鼠睾丸代谢，抑制S-180肿瘤细胞的生长和活力。在这些参数中，石蒜碱没有表现出明显的抑制作用。这些发现表明，归因于石蒜碱本身的生物作用可能至少部分归因于石蒜碱，石蒜碱在某些氧化条件下可转化为生成素。当石蒜碱-卵黄碱转化未开始时，石蒜碱的生长抑制和细胞毒性作用可能不明显。有证据支持这一假设。此外，还对石蒜碱转化为龙涎香碱的可能机制进行了评价。
The role of ungeremine (2), a natural metabolite of lycorine (1), in the growth-inhibitory and cytotoxic effects of 1 is evaluated. Ungeremine produced marked antibacterial action against ten bacterial isolates and significantly inhibited testicular metabolism in mice, and the growth and viability of S-180 tumour cells. Lycorine did not exhibit any noticeable inhibitory effect in these parameters. These findings suggest that the biological actions attributed to lycorine per se may be due, at least in part, to ungeremine, to which lycorine is converted under certain oxidizing conditions. Where lycorine-ungeremine conversion is not incipient, the growth-inhibiting and cytotoxic effects of lycorine may not manifest. Evidence is presented in support of this postulate. Additionally, plausible mechanisms of conversion of lycorine into ungeremine are appraised.