Potential use of compounds from sea cucumbers as MDM2 and CXCR4 inhibitors to control cancer cell growth.
Potential use of compounds from sea cucumbers as MDM2 and CXCR4 inhibitors to control cancer cell growth.
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海参作为MDM2和CXCR4抑制剂的潜在使用以控制癌细胞的生长。
DOI：
10.3892/etm.2018.6588
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发表时间：
2018-10
影响因子：
2.7
通讯作者：
Widodo N
中科院分区：
文献类型：
--
作者：
Wargasetia TL;Permana S;Widodo N
癌症治疗的无效性可能源于治疗与癌细胞中的各种突变的不相容性。寻找对不同类型的癌细胞有效的新型抗癌治疗仍然具有挑战性。先前的研究已经确定海参中的化合物能够抑制癌细胞的生长并诱导细胞凋亡。然而，在分子水平上控制癌细胞生长的潜在机制的信息仍然有限。目前的研究分析了colochiroside A，ds-echinoside A，philinopside E，鞘氨醇和stichoposide C作为抗癌靶蛋白抑制剂的潜力，包括小鼠双微体2同源物（MDM 2）和C-X-C趋化因子受体4型（CXCR 4）。MDM 2的抑制通过调节肿瘤蛋白53触发细胞凋亡，CXCR 4的抑制可能通过影响Janus激酶2/3信号转导子和转录信号传导通路的激活子以及蛋白酪氨酸激酶2来阻止癌细胞增殖和生长。利用分子对接的结合亲和力分析的结果显示，philinopside E和ds-echinoside A可以抑制MDM 2和CXCR 4。这些数据表明，这些活性化合物可能是有前途的细胞生长抑制剂，同时结合两个目标。此外，stichoposide C和colochiroside A被预测抑制CXCR 4。需要进一步的研究来验证上述化合物的体外活性。
Ineffectiveness of cancer therapy may originate in the incompatibility of the treatment with various mutations in the cancer cells. Finding novel anticancer treatments that work efficiently for varying types of cancer cells remains challenging. Previous studies have identified that compounds in sea cucumbers are capable of inhibiting the growth of cancer cells and inducing apoptosis. However, information on the underlying mechanisms controlling cancer cell growth at a molecular level remains limited. The current study analyzed the potential of colochiroside A, ds-echinoside A, philinopside E, sphingosine and stichoposide C as inhibitors for anticancer target proteins, including mouse double minute 2 homolog (MDM2) and C-X-C chemokine receptor type 4 (CXCR4). Inhibition of MDM2 triggers apoptosis through regulation of tumor protein 53 and CXCR4 inhibition may prevent cancer cell proliferation and growth by affecting the Janus kinase 2/3 signal transducer and activator of transcription signaling pathway and protein tyrosine kinase 2. The results of a binding affinity analysis using molecular docking revealed that philinopside E and ds-echinoside A may inhibit MDM2 and CXCR4. The data suggested that these active compounds may be promising inhibitors of cell growth by binding to two targets simultaneously. Furthermore, stichoposide C and colochiroside A were predicted to inhibit CXCR4. Additional research is needed to validate the in vitro activity of the aforementioned compounds.
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影响因子：
14.9
作者：
Kanehisa M;Goto S;Sato Y;Furumichi M;Tanabe M
通讯作者：
Tanabe M
通过 scFv 靶向递送 CXCR4-siRNA 用于 HER2( ) 乳腺癌治疗。
影响因子：
14
作者：
Jiang, Kuo;Li, Jia;Ma, Baoan
通讯作者：
Ma, Baoan
影响因子：
5.4
作者：
Bordbar S;Anwar F;Saari N
通讯作者：
Saari N
影响因子：
5.6
作者：
Chang, Max W.;Lindstrom, William;Belew, Richard K.
通讯作者：
Belew, Richard K.
DOI：
10.2147/dddt.s84932
发表时间：
2015
期刊：
Drug design, development and therapy
影响因子：
--
作者：
Xu C;Zhao H;Chen H;Yao Q
通讯作者：
Yao Q