Profound and redundant functions of arcuate neurons in obesity development.
Profound and redundant functions of arcuate neurons in obesity development.
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DOI：
10.1038/s42255-020-0229-2
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发表时间：
2020-08
影响因子：
20.8
通讯作者：
Tong Q
中科院分区：
文献类型：
--
作者：
Zhu C;Jiang Z;Xu Y;Cai ZL;Jiang Q;Xu Y;Xue M;Arenkiel BR;Wu Q;Shu G;Tong Q
The current obesity epidemic faces unmet mechanistic insights. It is known that the acute activity changes of a growing number of brain neurons rapidly alter feeding behaviour; however, how these changes translate to obesity development and the fundamental mechanism underlying brain neurons in controlling body weight remain elusive. Here, we show that chronic activation of hypothalamic arcuate GABAergic (GABA+), agouti-related protein (AgRP) neurons or arcuate non-AgRP GABA+ neurons all leads to obesity, which is similar the obese phenotype observed in ob/ob mice. Conversely, chronic inhibition of arcuate GABA+, but not AgRP neurons, reduces aging-related weigh gain and corrects ob/ob obesity. These results demonstrate that the modulation of Arc GABA+ neurons is a fundamental mechanism of body weight regulation and that arcuate GABA+ neurons are the major mediator of leptin action with a significant and redundant role in obesity development.
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影响因子：
16.2
作者：
Dhillon, H;Zigman, JM;Lowelll, BB
通讯作者：
Lowelll, BB
影响因子：
15.9
作者：
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影响因子：
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Zeng H
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影响因子：
64.8
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影响因子：
64.5
作者：
Chen Y;Lin YC;Kuo TW;Knight ZA
通讯作者：
Knight ZA