The Roles of Magnetic Resonance-Guided Focused Ultrasound in Pain Relief in Patients With Bone Metastases: A Systemic Review and Meta-Analysis.
The Roles of Magnetic Resonance-Guided Focused Ultrasound in Pain Relief in Patients With Bone Metastases: A Systemic Review and Meta-Analysis.
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磁共振引导聚焦超声在骨转移患者疼痛缓解中的作用：系统评价和荟萃分析
DOI：
10.3389/fonc.2021.617295
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发表时间：
2021
影响因子：
4.7
通讯作者：
Song D
中科院分区：
文献类型：
--
作者：
Han X;Huang R;Meng T;Yin H;Song D
癌痛是骨转移瘤最常见的肿瘤相关事件，严重影响患者的生活。MRI引导聚焦超声（MRgFUS）是缓解疼痛的治疗选择;然而，其有效性和安全性尚未得到充分研究。因此，我们旨在对报告骨转移患者MRgFUS的研究进行荟萃分析。使用PubMed、MEDLINE In-Process（美国国家医学图书馆）、美国国立卫生研究院（美国国家医学图书馆）、Embase（爱思唯尔）、Web of Science、CINAHL和科克伦图书馆收集了2007年8月至2019年9月期间关于骨转移患者MRgFUS治疗的随机对照试验（RCT）和非RCT。提取并分析了MRgFUS前后疼痛定量评估、缓解率和并发症的数据。本荟萃分析选择了15项符合条件的研究（362例患者）。基线时平均疼痛评分为6.74（95% CI：6.30-7.18），0-1周时为4.15（95% CI：3.31-4.99），1-5周时为3.09（95% CI：2.46-3.72），5-14周时为2.28（95% CI：1.37-3.19）。与基线相比，0-1周疼痛改善为2.54（95% CI：1.92-3.16，p < 0.01），1-5周为3.56（95% CI：3.11-4.02，p < 0.01），5-14周为4.22（95% CI：3.68-4.76，p < 0.01）。治疗后2周OMEDD较基线的变化为−15.11（95% CI：−34.73，4.50），治疗后1个月为−10.87（95% CI：−26.32，4.58），治疗后3个月为−5.53（95% CI：−20.44，9.38）。总体CR率为0.36（95%CI：0.24-0.48），PR率为0.47（95%CI：0.36-0.58），NR率为0.23（95%CI：0.13-0.34）。在14项研究（包括352例患者）中，记录了93例（26.4%）患者发生轻度并发症，5例（1.42%）患者发生严重并发症。该荟萃分析确定MRgFUS是缓解转移性骨肿瘤患者癌痛的可靠治疗选择，相关并发症可控。
Cancer pain, the most common skeleton-related event of bone metastases, significantly disturbs patients’ life. MRI-guided focused ultrasound (MRgFUS) is a therapeutic option to relieve pain; however, its efficacy and safety have not been fully explored. Therefore, we aim to conduct a meta-analysis on studies reporting MRgFUS for patients with bone metastases. Randomized controlled trials (RCT) and non-RCTs on MRgFUS treatment for patients with bone metastases were collected using PubMed, MEDLINE In-Process (US National Library of Medicine), National Institutes of Health (US National Library of Medicine), Embase (Elsevier), Web of Science, CINAHL, and the Cochrane Library between August 2007 and September 2019. Data on quantitative pain assessment before/after MRgFUS, response rate, and complication were extracted and analyzed. Fifteen eligible studies with 362 patients were selected in this meta-analysis. The average pain score was 6.74 (95% CI: 6.30–7.18) at baseline, 4.15 (95% CI: 3.31–4.99) at 0–1 week, 3.09 (95% CI: 2.46–3.72) at 1–5 weeks, and 2.28 (95% CI: 1.37–3.19) at 5–14 weeks. Compared with baseline, the pain improvement at 0–1 week was 2.54 (95% CI: 1.92–3.16, p < 0.01), at 1–5 weeks was 3.56 (95% CI: 3.11–4.02, p < 0.01), and at 5–14 weeks was 4.22 (95% CI: 3.68–4.76, p < 0.01). Change from baseline in OMEDD at 2 weeks after treatment was −15.11 (95% CI: −34.73, 4.50), at 1 month after treatment was −10.87 (95% CI: −26.32, 4.58), and at 3 months after treatment was −5.53 (95% CI: −20.44, 9.38). The overall CR rate was 0.36 (95% CI: 0.24–0.48), PR rate was 0.47 (95% CI: 0.36–0.58), and NR rate was 0.23 (95% CI: 0.13–0.34). Among 14 studies including 352 patients, 93 (26.4%) patients with minor complications and 5 (1.42%) patients with major complications were recorded. This meta-analysis identifies MRgFUS as a reliable therapeutic option to relieve cancer pain for patients with metastatic bone tumors with controllable related complications.
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影响因子：
10.3
作者：
Hartsell, WF;Scott, CB;DeSilvio, M
通讯作者：
DeSilvio, M
影响因子：
2.1
作者：
BONICA, JJ
通讯作者：
BONICA, JJ
影响因子：
29.4
作者：
Ceyhan, Gueralp O.;Bergmann, Frank;Friess, Helmut
通讯作者：
Friess, Helmut
DOI：
10.1186/s40349-018-0117-3
发表时间：
2018-11-30
期刊：
JOURNAL OF THERAPEUTIC ULTRASOUND
影响因子：
--
作者：
Bertrand, Anne-Sophie;Iannessi, Antoine;Thyss, Antoine
通讯作者：
Thyss, Antoine
DOI：
10.1016/j.jvir.2014.08.027
发表时间：
2014-11
期刊：
Journal of vascular and interventional radiology : JVIR
影响因子：
--
作者：
Ahmed M;Solbiati L;Brace CL;Breen DJ;Callstrom MR;Charboneau JW;Chen MH;Choi BI;de Baère T;Dodd GD 3rd;Dupuy DE;Gervais DA;Gianfelice D;Gillams AR;Lee FT Jr;Leen E;Lencioni R;Littrup PJ;Livraghi T;Lu DS;McGahan JP;Meloni MF;Nikolic B;Pereira PL;Liang P;Rhim H;Rose SC;Salem R;Sofocleous CT;Solomon SB;Soulen MC;Tanaka M;Vogl TJ;Wood BJ;Goldberg SN;International Working Group on Image-Guided Tumor Ablation;Interventional Oncology Sans Frontières Expert Panel;Technology Assessment Committee of the Society of Interventional Radiology;Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe
通讯作者：
Standard of Practice Committee of the Cardiovascular and Interventional Radiological Society of Europe