MIND diet slows cognitive decline with aging.
MIND diet slows cognitive decline with aging.
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DOI：
10.1016/j.jalz.2015.04.011
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Aggarwal NT
中科院分区：
文献类型：
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作者：
Morris MC;Tangney CC;Wang Y;Sacks FM;Barnes LL;Bennett DA;Aggarwal NT
地中海饮食和DASH饮食已被证明可以减缓认知能力下降，然而，这两种饮食都不是专门针对痴呆症预防的营养文献。我们设计了MIND饮食评分，专门捕捉被证明具有神经保护作用的饮食成分，并将其与记忆和衰老项目960名参与者平均4.7年的认知变化联系起来。在调整后的混合模型中，MIND评分与总体认知评分下降较慢（β=0.0092; p<0.0001）和5个认知领域中的每一个呈正相关。MIND饮食评分最高的三分之一与最低的三分之一之间的下降率差异相当于年龄小7.5岁。研究结果表明，MIND饮食大大减缓了认知能力随年龄的下降。需要在饮食干预试验中复制这些发现，以验证其与大脑健康的相关性。
The Mediterranean and DASH diets have been shown to slow cognitive decline, however, neither diet is specific to the nutrition literature on dementia prevention. We devised the MIND diet score that specifically captures dietary components shown to be neuroprotective and related it to change in cognition over an average 4.7 years among 960 participants of the Memory and Aging Project. In adjusted mixed models, the MIND score was positively associated with slower decline in global cognitive score (β=0.0092; p<.0001) and with each of 5 cognitive domains. The difference in decline rates for being in the top tertile of MIND diet scores versus the lowest was equivalent to being 7.5 years younger in age. The study findings suggest that the MIND diet substantially slows cognitive decline with age. Replication of these findings in a dietary intervention trial would be required to verify its relevance to brain health.