COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus
COVID-19 severity and mortality in patients with chronic lymphocytic leukemia: a joint study by ERIC, the European Research Initiative on CLL, and CLL Campus
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DOI：
10.1038/s41375-020-0959-x
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发表时间：
2020-07-09
期刊：
影响因子：
11.4
通讯作者：
Ghia, Paolo
中科院分区：
文献类型：
--
作者：
Scarfo, Lydia;Chatzikonstantinou, Thomas;Ghia, Paolo
慢性淋巴细胞白血病（CLL）是一种以免疫缺陷为特征的老年人疾病。因此，CLL患者可能被认为更容易受到COVID-19严重并发症的影响。我们进行了这项回顾性国际多中心研究，以描述CLL患者的COVID-19病程，并确定潜在的预后预测因素。在2020年3月28日至2020年5月22日期间确诊的190名CLL和确诊COVID-19患者中，151名（79%）出现严重COVID-19（需要氧气和/或重症监护入院）。严重的COVID-19与更高的年龄（>= 65岁）相关（比值比3.72 [95% CI 1.79-7.71]）。只有60名（39.7%）严重COVID-19患者正在接受或近期接受过（
Chronic lymphocytic leukemia (CLL) is a disease of the elderly, characterized by immunodeficiency. Hence, patients with CLL might be considered more susceptible to severe complications from COVID-19. We undertook this retrospective international multicenter study to characterize the course of COVID-19 in patients with CLL and identify potential predictors of outcome. Of 190 patients with CLL and confirmed COVID-19 diagnosed between 28/03/2020 and 22/05/2020, 151 (79%) presented with severe COVID-19 (need of oxygen and/or intensive care admission). Severe COVID-19 was associated with more advanced age (>= 65 years) (odds ratio 3.72 [95% CI 1.79-7.71]). Only 60 patients (39.7%) with severe COVID-19 were receiving or had recent (