Event-related brain potential correlates of prospective memory in symptomatically remitted male patients with schizophrenia.
Event-related brain potential correlates of prospective memory in symptomatically remitted male patients with schizophrenia.
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DOI：
10.3389/fnbeh.2015.00262
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发表时间：
2015
影响因子：
3
通讯作者：
Cui H
中科院分区：
文献类型：
--
作者：
Chen G;Zhang L;Ding W;Zhou R;Xu P;Lu S;Sun L;Jiang Z;Li H;Li Y;Cui H
前瞻性记忆（Prospective Memory，PM）是指记住在未来执行预期动作的能力。虽然PM缺陷是精神分裂症的一个突出的损害，仍然很少有人知道PM的性质在精神分裂症患者中的症状缓解。为了解决这个问题，事件相关脑电位（ERPs）记录从20例精神分裂症患者和20名健康对照者在事件为基础的PM范式。行为学结果表明，精神分裂症患者的症状缓解表现不佳的PM任务与健康对照组相比。在神经水平上，N300，与PM线索检测相关的ERPs的一个组成部分，在这两个组中是可靠的，这表明一定程度的功能恢复的过程支持线索检测在精神分裂症患者中。相比之下，前瞻性积极性的幅度，一个组成部分的事件相关电位与PM意图检索，显着衰减在精神分裂症患者相对于健康对照组。此外，在这些患者中，前瞻积极性的幅度和PM任务的准确性之间存在显著的正相关，这表明患者在该任务上的表现不佳可能是由于未能从记忆中恢复PM线索诱导的意图。这些结果提供了证据的存在改变PM处理的精神分裂症患者，其特征是选择性缺陷的回顾性组成部分（意图检索）的PM。因此，这些发现揭示了新的神经生理过程的基础PM精神分裂症患者在临床缓解期。
Prospective memory (PM) refers to the ability to remember to perform intended actions in the future. Although PM deficits are a prominent impairment in schizophrenia, little is still known about the nature of PM in symptomatically remitted patients with schizophrenia. To address this issue, event-related brain potentials (ERPs) were recorded from 20 symptomatically remitted patients with schizophrenia and 20 healthy controls during an event-based PM paradigm. Behavioral results showed that symptomatically remitted patients with schizophrenia performed poorly on the PM task compared with healthy controls. On the neural level, the N300, a component of the ERPs related to PM cue detection, was reliable across these two groups, suggesting a degree of functional recovery of processes supporting cue detection in patients with symptomatically remitted schizophrenia. By contrast, the amplitude of the prospective positivity, a component of the ERPs related to PM intention retrieval, was significantly attenuated in symptomatically remitted schizophrenia patients relative to healthy controls. Furthermore, a significant positive correlation between the amplitude of the prospective positivity and accuracy on the PM task was found in those patients, indicating that patients’ poor performance on this task may result from the failure to recover PM cue-induced intention from memory. These results provide evidence for the existence of altered PM processing in patients with symptomatically remitted schizophrenia, which is characterized by a selective deficit in retrospective component (intention retrieval) of PM. Therefore, these findings shed new light on the neurophysiological processes underlying PM in schizophrenia patients during clinical remission.