Optimisation of dark adaptation time required for mesopic microperimetry
Optimisation of dark adaptation time required for mesopic microperimetry
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DOI：
10.1136/bjophthalmol-2018-312253
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发表时间：
2019-08-01
影响因子：
4.1
通讯作者：
Jolly, Jasleen Kaur
中科院分区：
文献类型：
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作者：
Han, Ruofan Connie;Gray, Joanna Monika;Jolly, Jasleen Kaur
背景黄斑完整性评估（马亚）微视野计越来越多地用于临床和研究环境中，以评估点视网膜敏感性和固视稳定性。测试发生在中间视觉条件下，通常在一段时间的黑暗适应之后。我们的目的是确定优化微视野检查性能所需的最小适应长度。方法对40例年龄18-73岁的健康受试者的40只右眼进行马亚微视野检查，使用10 - 2网格，在环境光暴露后进行0、5、10、15、20和30 min的中间视觉适应，无眼部病变，视力至少为0.1 logMAR。10名无脉络膜参与者的10只右眼在0和20分钟的适应后也进行了测试。我们进一步测试了10名健康参与者的10只右眼在强光暴露后的适应0，10和20分钟。我们比较了不同时间点的阈值敏感性和注视稳定性的变化。结果在环境光暴露后，健康参与者或无脉络膜患者的微视野检查性能并没有随着适应时间的增加而改善。在强光照射后，我们发现微视野阈值在适应10 min后有所改善，但在20 min时没有进一步改善。结论在环境光照射后进行马亚微视野检查之前不需要中间视适应。在暴露于强光刺激（例如检眼镜检查或视网膜成像）后，10分钟的适应就足够了。暗适应所需的短暂时间对应于视锥适应曲线，并为视锥介导的中间视觉条件下的中央视网膜功能提供了进一步的证据。
Background Macular Integrity Assessment (MAIA) microperimetry is increasingly used in clinical and research settings to assess point retinal sensitivity and fixation stability. Testing occurs under mesopic conditions, commonly after a period of dark adaptation. Our aim was to identify the minimum length of adaptation required to optimise microperimetry performance. Methods MAIA microperimetry using the 10-2 grid was performed on 40 right eyes of 40 healthy participants aged 18-73 with no ocular pathology and vision of at least 0.1 logMAR after ambient light exposure, with 0, 5, 10, 15, 20 and 30 min of adaptation in mesopic settings. Ten right eyes of 10 participants with choroideremia were also tested following 0 and 20 min of adaptation. We further tested 10 right eyes of 10 healthy participants after bright light exposure, with 0, 10 and 20 min of adaptation. We compared changes in threshold sensitivity and fixation stability across time points. Results Microperimetry performance did not improve with increasing adaptation time in healthy participants or patients with choroideremia after ambient light exposure. After bright light exposure, we found microperimetry thresholds improved after 10 min of adaptation, but did not improve further at 20 min. Conclusion Mesopic adaptation is not required before MAIA microperimetry after exposure to ambient light. Ten minutes of adaptation is sufficient after exposure to a bright light stimulus, such as ophthalmoscopy or retinal imaging. The brief time of dark adaptation required corresponds to cone adaptation curves and provides further evidence for cone-mediated central retinal function under mesopic conditions.