Furosemide differentially relaxes airway and vascular smooth muscle in fetal, newborn, and adult guinea pigs.
Furosemide differentially relaxes airway and vascular smooth muscle in fetal, newborn, and adult guinea pigs.
复制标题
速尿对胎儿、新生儿和成年豚鼠的气道和血管平滑肌有不同的松弛作用。
DOI：
10.1164/ajrccm/146.5_pt_1.1192
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Nakamura,KT
中科院分区：
文献类型：
--
作者：
Stevens,EL;Uyehara,CF;Southgate,WM;Nakamura,KT
速尿，一种CI依赖性Na+抑制剂，K+共转运蛋白是新生儿最常用的利尿剂。最近，呋塞米也被证明可以降低成人的支气管高反应性，尽管关于呋塞米对未成熟动物平滑肌的直接作用知之甚少。这项体外研究旨在确定个体发育过程中呋塞米对气道和血管平滑肌的作用。胎儿、新生儿和成人的胸外气管（ET）、主支气管主干、主肺动脉和胸主动脉环段
Furosemide, an Inhibitor of CI-dependent Na.., K+ cotranspart, Is the most frequently used diuretic in newborns. Recently, furosemide was also demonstrated to decrease bronchial hyperresponsiveness In adUlts, although little Is known about the direct effect of furosemide on smooth muscle of Immature animals. This in vitrostudy was designed to determine the action of furosemide on airway and vascular smooth muscle during ontogeny. Extrathoraclc trachea (ET), main stem bronchi, main pUlmonary artery, and thoracic aorta ring segments from fetal, newborn, and adult