Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning
Abnormal ventromedial prefrontal cortex function in children with psychopathic traits during reversal learning
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DOI：
10.1001/archpsyc.65.5.586
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发表时间：
2008-05-01
影响因子：
--
通讯作者：
Blair, James R.
中科院分区：
文献类型：
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作者：
Finger, Elizabeth C.;Marsh, Abigail A.;Blair, James R.
内容：具有精神病特征和行为或对立违抗性障碍的儿童和成人表现出决策能力差，逆转学习能力受损。然而，这种损害的神经基础以前没有被调查。此外，尽管精神病特征和注意力缺陷/多动障碍的高共患病率，据我们所知，没有研究试图区分儿童期精神病特征和注意力缺陷/多动障碍的神经相关性。目的：确定精神病特征加行为或对立违抗性障碍儿童逆转学习障碍的神经区域。设计：病例对照研究。设置：参与者：42名10至17岁的青少年：14名患有精神病特征和对立违抗性障碍或行为障碍，14名仅患有注意力缺陷/多动障碍，14名健康对照。在概率逆转任务期间通过功能性磁共振成像测量的血氧水平依赖信号。与注意缺陷/多动障碍儿童和健康儿童相比，精神病儿童在惩罚性逆转错误时，前额叶腹内侧区（Brodmann 10区）的反应异常（P
Context: Children and adults with psychopathic traits and conduct or oppositional defiant disorder demonstrate poor decision making and are impaired in reversal learning. However, the neural basis of this impairment has not previously been investigated. Furthermore, despite high comorbidity of psychopathic traits and attention-deficit/hyperactivity disorder, to our knowledge, no research has attempted to distinguish neural correlates of childhood psychopathic traits and attentiondeficit/hyperactivity disorder.Objective: To determine the neural regions that underlie the reversal learning impairments in children with psychopathic traits plus conduct or oppositional defiant disorder.Design: Case-control study.Setting: Government clinical research institute.Participants: Forty-two adolescents aged 10 to 17 years: 14 with psychopathic traits and oppositional defiant disorder or conduct disorder, 14 with attention-cleficit/hyperactivity disorder only, and 14 healthy controls.Main Outcome Measure: Blood oxygenation level-dependent signal as measured via functional magnetic resonance imaging during a probabilistic reversal task.Results: Children with psychopathic traits showed abnormal responses within the ventromedial prefrontal cortex (Brodmann area 10) during punished reversal errors compared with children with attention-deficit/hyperactivity disorder and healthy children (P