PREFERENTIAL SELECTION OF CENTRAL PATHWAYS BY REGENERATING OPTIC FIBERS
PREFERENTIAL SELECTION OF CENTRAL PATHWAYS BY REGENERATING OPTIC FIBERS
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DOI：
10.1016/0014-4886(63)90093-1
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发表时间：
1963-01-01
影响因子：
5.3
通讯作者：
SPERRY, RW
中科院分区：
文献类型：
--
作者：
ATTARDI, DG;SPERRY, RW
金鱼视神经再生的时间过程和一般特征，在神经节段后3至67天之间的间隔时间制备的切片。然后，通过去除视网膜的特定部分与视神经的完整部分的组合来测试来自视网膜的不同部分的纤维的差异路线和目的地偏好。随着视网膜背侧的一半被破坏，幸存的腹侧纤维在神经瘢痕之外分离，并选择性地进入内侧束与背侧顶盖连接。相反，当背侧视网膜保持完整时，再生纤维选择性地填充外侧皮层和腹侧顶盖。纤维从后（颞）半视网膜侵入顶盖的前部，并没有延伸到后面的地区。相反，来自前半视网膜的神经元绕过前区支配后顶盖。来自视网膜中心的纤维在到达顶盖内的平行层后，绕过边缘的丛状层，仅在中央区连接。边缘区的丛状层只有在周边视网膜有纤维时才受神经支配。这些结果为视神经纤维在脑中枢的有序选择性终止提供了直接的显微证据。他们还表现出一个显着的和意想不到的（大概是趋化性）选择性的倾向，不同的视网膜纤维组选择和遵循特定的中央通路的途中，他们的突触目的地。论文认为，特定的化学亲和力管理的形成和维持的神经元协会的基础上，目前的结果，包括中央纤维通路的图案。
The time-course and general features of optic nerve regeneration in goldfish were followed in sections prepared at spaced intervals between 3 and 67 days after nerve section. Differential route and destination preferences of fibers from different parts of the retina were then tested by removing specific portions of the retina in combination with complete section of the optic nerve. With the dorsal half of the retina destroyed, surviving ventral fibers became segregated beyond the nerve scar and selectively entered the medial tract to connect with dorsal tectum. Conversely, when dorsal retina remained intact, the regenerating fibers filled selectively the lateral t ract and the ventral tectum. Fibers from the posterior (temporal) hemiretina invaded the anterior portion of the tectum and did not extend into the posterior regions. Conversely, those from the anterior hemiretina bypassed the anterior zones to innervate the posterior tectum. Fibers from the center of the retina, after reaching the parallel layer within the tectum, bypassed the plexiform layer in the margin to connect only in the central zone. The plexiform layer in the marginal zones was innervated only when fibers were available from the peripheral retina. The results furnish direct microscopical evidence for the orderly selective termination of optic fibers in the brain centers. They also demonstrate a remarkable and unexpected (presumably chemotactic) selectivity in the tendency of different retinal fiber groups to choose and to follow specific central pathways en route to their synaptic destinations. The thesis that specific chemical affinities govern the formation and maintenance of neuronal associations is extended on the basis of the present results to include the patterning of central fiber pathways.