Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment.
Delivery of a chemotherapeutic drug using novel hollow carbon spheres for esophageal cancer treatment.
复制标题
使用新型空心碳球输送化疗药物治疗食管癌
DOI：
10.2147/ijn.s142916
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发表时间：
2017
影响因子：
8
通讯作者：
Wang QL
中科院分区：
文献类型：
--
作者：
Zhang L;Yao M;Yan W;Liu X;Jiang B;Qian Z;Gao Y;Lu XJ;Chen X;Wang QL
低毒性和高疗效是影响纳米材料辅助给药系统临床应用的关键因素。在这项研究中，新的空心碳球（HCSs）具有窄尺寸分布的发展。除了证明其易于大规模生产的合成外，我们还在体外证明了HCS具有高载药能力，较低的细胞毒性和在低pH下的最佳药物释放曲线，与肿瘤微环境中的pH相似。HCS还显示出良好的免疫相容性，并可迅速分布在细胞质中以逃避溶酶体清除。更重要的是，HCS可以有效地将多柔比星（代表性化疗药物）递送到肿瘤部位，这导致在食管异种移植癌模型中显著抑制肿瘤生长。这也延长了循环时间，改变了药物的生物分布。总之，本研究揭示了一种新的药物递送系统的靶向肿瘤治疗。
Low toxicity and high efficacy are the key factors influencing the real-world clinical applications of nanomaterial-assisted drug delivery. In this study, novel hollow carbon spheres (HCSs) with narrow size distribution were developed. In addition to demonstrating their ease of synthesis for large-scale production, we also demonstrated in vitro that the HCSs possessed high drug-loading capacity, lower cell toxicity, and optimal drug release profile at low pH, similar to the pH in the tumor microenvironment. The HCSs also displayed excellent immunocompatibility and could rapidly distribute themselves in the cytoplasm to escape lysosomal clearance. More importantly, the HCSs could efficiently deliver doxorubicin (a representative chemotherapeutic drug) to tumor sites, which resulted in significant inhibition of tumor growth in an esophageal xenograft cancer model. This also prolonged the circulation time and altered the biodistribution of the drug. In conclusion, this study revealed a novel drug delivery system for targeted tumor therapy.