A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale
A novel homobimetallic nickel complex for the asymmetric direct Mannich reaction of imines: a practical method on a multi-gram scale
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一种用于亚胺不对称直接曼尼希反应的新型同质双金属镍配合物：一种多克规模的实用方法
DOI：
10.1039/c7cc06468c
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Hui Zhou
中科院分区：
文献类型：
--
作者：
Shixiong Zhang;Ping Deng;Jing Zhou;Mouxiong Liu;Guojuan Liang;Yan Xiong;Hui Zhou
合成了一种新型双核镍配合物，用于丙二酸酯与N-对甲苯基芳基亚胺的直接Mannich反应，催化剂负载量低(0.1-0.05mol%)，制备规模(5-50 mmol)。通过对照实验、ESI-HRMS和密度泛函理论计算，验证了活性物种的结构。
A novel dinuclear Ni complex has been developed for the direct Mannich reaction of malonates with N-tosyl aryl imines with a low catalyst loading (0.1–0.05 mol%) on a preparative scale (5–50 mmol). The structure of the active species was verified via control experiments, ESI-HRMS, and DFT calculations.