Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort
Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort
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DOI：
10.1136/ard.2006.060293
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发表时间：
2007-05-01
影响因子：
27.4
通讯作者：
Weisman, Michael H.
中科院分区：
文献类型：
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作者：
Lee, Wonuk;Reveille, John D.;Weisman, Michael H.
目的：在强直性脊柱炎队列结局的前瞻性研究中检查男性和女性的临床和影像学特征，这是一项针对AS患者的大型明确的横断面研究，目的是了解性别在确定强直性脊柱炎严重程度方面的影响。方法：对302名男性和100名女性AS>= 20年的患者进行了广泛的临床评估和脊柱X线检查。使用Bath强直性脊柱炎放射学指数脊柱（BASRI-脊柱）评分（范围2-12）对X线片进行评分。功能障碍的测量采用Bath强直性脊柱炎功能指数（BASFI）和脊柱关节病健康评估问卷（HAQ-S）。男性未校正的BASRI脊柱评分中位数为10，女性为6.5（p <0.05）。
Objective: To examine the clinical and radiographic features in men and women in the Prospective Study of Outcomes in Ankylosing Spondylitis cohort, a large well-defined cross-sectional study of patients with AS, in order to understand the influence of gender in determining the severity of ankylosing spondylitis.Methods: Extensive clinical assessments and spine radiographs were performed in 302 men and 100 women with AS of >= 20 years duration. Radiographs were scored using the Bath Ankylosing Spondylitis Radiographic Index Spine (BASRI-spine) score ( range 2-12). Functional impairment was measured by the Bath Ankylosing Spondylitis Functional Index (BASFI) and the Health Assessment Questionnaire for the Spondyloarthropathies (HAQ-S).Results: Radiographic severity was worse among men. The unadjusted median BASRI-spine score for men was 10, compared with 6.5 for women (p