Who’s talking to whom: microbiome-enteric nervous system interactions in early life
Who’s talking to whom: microbiome-enteric nervous system interactions in early life
复制标题
谁在和谁说话：生命早期微生物组与肠神经系统的相互作用
DOI：
10.1152/ajpgi.00166.2022
复制
发表时间：
2023
影响因子：
4.5
通讯作者：
Ratcliffe, Elyanne M.
中科院分区：
文献类型：
--
作者：
Ganz, Julia;Ratcliffe, Elyanne M.
肠神经系统（ENS）是胃肠道（GI）的内在神经系统，调节重要的GI功能，包括运动、营养吸收和免疫反应。ENS的发育开始于早期器官发生，并在进食开始后继续发育，并持续可塑性直至成年。越来越多的人认识到，肠道微生物群和ENS在关键时期相互作用，对正常发育和潜在的疾病发病机制有影响。在这篇综述中，我们专注于从小鼠和斑马鱼模型系统的见解，比较和对比每个模型如何可以在阐明ENS和微生物之间的双向通信。在这篇综述的最后，我们进一步概述了对人类疾病的影响，并强调了可以引领该领域向前发展的研究创新。
The enteric nervous system (ENS) is the intrinsic nervous system of the gastrointestinal tract (GI) and regulates important GI functions, including motility, nutrient uptake, and immune response. The development of the ENS begins during early organogenesis and continues to develop once feeding begins, with ongoing plasticity into adulthood. There has been increasing recognition that the intestinal microbiota and ENS interact during critical periods, with implications for normal development and potential disease pathogenesis. In this review, we focus on insights from mouse and zebrafish model systems to compare and contrast how each model can serve in elucidating the bidirectional communication between the ENS and the microbiome. At the end of this review, we further outline implications for human disease and highlight research innovations that can lead the field forward.