Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in Drosophila.
Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in Drosophila.
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DOI：
10.1534/g3.114.015040
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发表时间：
2014-11-11
期刊：
影响因子：
--
通讯作者：
French RL
中科院分区：
文献类型：
--
作者：
Logan-Garbisch T;Bortolazzo A;Luu P;Ford A;Do D;Khodabakhshi P;French RL
发育过程中的乙醇暴露会导致一系列生理和行为发育异常。在哺乳动物中，这些异常统称为胎儿酒精效应（FAE）或胎儿酒精谱系障碍（FASD）。我们已经建立了一个果蝇模型FASD和先前表明，发育中的乙醇暴露在苍蝇导致胰岛素样肽（dILP）及其受体的表达减少。在这项工作中，我们将观察结果与脂肪酸代谢和脂质积累的失调联系起来。此外，我们表明，在果蝇发育乙醇暴露导致氧化应激，这种压力是一个主要原因的发展致死性和延迟与乙醇暴露，最后，乙醇增加氧化应激的机制之一是通过异常的脂肪酸代谢。这些数据表明，乙醇引起FASD相关症状的一种以前未表征的机制。
Ethanol exposure during development causes an array of developmental abnormalities, both physiological and behavioral. In mammals, these abnormalities are collectively known as fetal alcohol effects (FAE) or fetal alcohol spectrum disorder (FASD). We have established a Drosophila melanogaster model of FASD and have previously shown that developmental ethanol exposure in flies leads to reduced expression of insulin-like peptides (dILPs) and their receptor. In this work, we link that observation to dysregulation of fatty acid metabolism and lipid accumulation. Further, we show that developmental ethanol exposure in Drosophila causes oxidative stress, that this stress is a primary cause of the developmental lethality and delay associated with ethanol exposure, and, finally, that one of the mechanisms by which ethanol increases oxidative stress is through abnormal fatty acid metabolism. These data suggest a previously uncharacterized mechanism by which ethanol causes the symptoms associated with FASD.
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影响因子：
4.3
作者：
McClure KD;French RL;Heberlein U
通讯作者：
Heberlein U
影响因子：
5.3
作者：
Berruyer, C;Martin, FM;Galland, F
通讯作者：
Galland, F
影响因子：
4.8
作者：
Listenberger, LL;Ory, DS;Schaffer, JE
通讯作者：
Schaffer, JE
影响因子：
2.3
作者：
Mitchell, JJ;Paiva, M;Heaton, MB
通讯作者：
Heaton, MB
DOI：
10.1111/j.1530-0277.2000.tb02019.x
发表时间：
2000-04-01
影响因子：
3.2
作者：
Heaton, MB;Mitchell, JJ;Paiva, M
通讯作者：
Paiva, M