High frequencies of Y chromosome lineages characterized by E3b1, DYS19-11, DYS392-12 in Somali males
High frequencies of Y chromosome lineages characterized by E3b1, DYS19-11, DYS392-12 in Somali males
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DOI：
10.1038/sj.ejhg.5201390
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发表时间：
2005-07-01
影响因子：
5.2
通讯作者：
Morling, N
中科院分区：
文献类型：
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作者：
Sanchez, JJ;Hallenberg, C;Morling, N
我们对 201 名索马里男性 Y 染色体上的 45 个双等位标记和 11 个 STR 系统进行了基因分型。此外，还对 65 名撒哈拉以南西非人、59 名土耳其人和 64 名伊拉克人进行了双等位 Y 染色体标记分型。在索马里人中，鉴定出 14 个 Y 染色体单倍群，包括 E3b1 (77.6%) 和 K2 (10.4%)。在 75.1% 的索马里男性中发现了带有罕见 DYS19-11 等位基因（也称为 E3b1 簇 c）的单倍群 E3b1，70.6% 的索马里 Y 染色体为 E3b1、DYS19-11、DYS392-12、DYS437-14、DYS438-11 和DYS393-13。八个 Y-STR（“最小单倍型”）的单倍型多样性为 0.9575，而欧洲和亚洲人群的平均多样性为 0.9974 和 0.9996。在撒哈拉以南的西非人中，仅发现了四个单倍群。 89.2% 的样本中发现了西非分支 E3a，但未观察到单倍群 E3b1。在土耳其人中，发现了 12 个单倍群，包括 J2*(xJ2f2) (27.1%)、R1b3*(xR1b3d, R1b3f) (20.3%)、E3b3 和 R1a1*(xR1a1b)（均为 11.9%）。在伊拉克人中，鉴定出 12 个单倍群，包括 J2*(xJ2f2) (29.7%) 和 J*(xJ2) (26.6%)。数据表明，索马里男性人口是东非人口的一个分支，与埃塞俄比亚和肯尼亚北部的奥罗莫人密切相关，其主要E3b1簇c谱系在4000-5000年前被引入索马里人口，索马里男性人口中大约15%的Y染色体来自欧亚大陆，大约5%来自撒哈拉以南非洲。
We genotyped 45 biallelic markers and 11 STR systems on the Y chromosome in 201 male Somalis. In addition, 65 sub-Saharan Western Africans, 59 Turks and 64 Iraqis were typed for the biallelic Y chromosome markers. In Somalis, 14 Y chromosome haplogroups were identified including E3b1 (77.6%) and K2 (10.4%). The haplogroup E3b1 with the rare DYS19-11 allele (also called the E3b1 cluster c) was found in 75.1% of male Somalis, and 70.6% of Somali Y chromosomes were E3b1, DYS19-11, DYS392- 12, DYS437-14, DYS438-11 and DYS393-13. The haplotype diversity of eight Y-STRs ('minimal haplotype') was 0.9575 compared to an average of 0.9974 and 0.9996 in European and Asian populations. In sub-Saharan Western Africans, only four haplogroups were identified. The West African clade E3a was found in 89.2% of the samples and the haplogroup E3b1 was not observed. In Turks, 12 haplogroups were found including J2*(xJ2f2) (27.1%), R1b3*(xR1b3d, R1b3f) (20.3%), E3b3 and R1a1*(xR1a1b) (both 11.9%). In Iraqis, 12 haplogroups were identified including J2*(xJ2f2) (29.7%) and J*(xJ2) (26.6%). The data suggest that the male Somali population is a branch of the East African population-closely related to the Oromos in Ethiopia and North Kenya - with predominant E3b1 cluster c lineages that were introduced into the Somali population 4000 - 5000 years ago, and that the Somali male population has approximately 15% Y chromosomes from Eurasia and approximately 5% from sub-Saharan Africa.